Therapeutic agent delivery apparatus with direct mechanical ventricular assistance capability

• US 20050234289A1
• Filed: 06/02/2005
• Published: 10/20/2005
• Est. Priority Date: 06/26/2003
• Status: Abandoned Application

• Current Assignee: Myocardiocare, Inc.
• Original Assignee: Myocardiocare, Inc.
• Inventors: MacDonald, Stuart G., Anstadt, Mark P., Helfer, Jeffrey L., Anstadt, George W., Anstadt, George L.
• Application Number:
  US11/143,542
• Publication Number:
  US 20050234289A1
• Time in Patent Office: Days
• US Class Current: 600/16
• CPC Class Codes: A61F 2/2481 Devices outside the heart wall, e.g. bags, strips or bands
• CPC Class Codes: A61M 2205/32 with radio-opaque indicia
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/202 partial carbon oxide pressure, e.g. partial dioxide pressure (P-CO2)
• CPC Class Codes: A61M 2230/205 partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 60/191 mechanically acting upon the outside of the patient's native heart, e.g. compressive structures placed around the heart
• CPC Class Codes: A61M 60/289 Devices for mechanical circulatory actuation assisting the residual heart function by means mechanically acting upon the patient's native heart or blood vessel structure, e.g. direct cardiac compression [DCC] devices
• CPC Class Codes: A61M 60/468 the force acting on the actuation means being hydraulic or pneumatic
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/523 using blood flow data, e.g. from blood flow transducers
• CPC Class Codes: A61M 60/531 using blood pressure data, e.g. from blood pressure sensors
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence

Abstract

A therapeutic apparatus for delivering at least one therapeutic agent directly and preferentially to a desired tissue to be treated, comprising at least one membrane adapted to deliver the therapeutic agent to the desired tissue, wherein the membrane is in contact with at least a part of the desired tissue to be treated; and at least one shell surrounding the membrane, wherein the shell isolates the membrane from tissues other than the desired tissue to be treated. In one embodiment, the apparatus is a direct mechanical ventricular assistance apparatus comprising a liner in which the membrane is formed.

Claims

1. A therapeutic apparatus for delivering at least one therapeutic agent directly and preferentially to a desired tissue to be treated, said apparatus comprising:

a. at least one membrane comprised of means to deliver said agent to said desired tissue, said membrane being in contact with at least a part of said desired tissue to be treated; and

b. at least one shell surrounding said membrane, said shell isolating said at least one membrane from tissues other than said desired tissue to be treated.

2. The apparatus as recited in claim 1, wherein said at least one therapeutic agent is selected from the group consisting of anti-inflammatory agents, gene therapy agents, gene transfer agents, stem cells, chemo-attractants, cell regeneration agents, ventricular remodeling agents, anti-infection agents, tumor suppressants, tissue and/or cell engineering agents, imaging contrast agents, tissue staining agents, nutrients, and mixtures thereof.

3. The apparatus as recited in claim 1, wherein said at least one membrane is formed as a liner.

4. The apparatus as recited in claim 3, wherein said at least one therapeutic agent is impregnated in said at least one membrane.

5. The apparatus as recited in claim 3, wherein said liner further comprises an impermeable film separated from said membrane by a gap, and wherein said therapeutic agent is contained in said gap.

6. The apparatus as recited in claim 3, wherein said liner is detachable from said apparatus.

7. The apparatus as recited in claim 6, wherein said at least one therapeutic agent is selected from the group consisting of anti-inflammatory agents, gene therapy agents, gene transfer agents, stem cells, chemo-attractants, cell regeneration agents, ventricular remodeling agents, anti-infection agents, tumor suppressants, tissue and/or cell engineering agents, imaging contrast agents, tissue staining agents, nutrients, and mixtures thereof.

8. The apparatus as recited in claim 3, wherein said therapeutic agent is selected from the group consisting of anti-inflammatory agents, gene therapy agents, gene transfer agents, stem cells, chemo-attractants, cell regeneration agents, ventricular remodeling agents, anti-infection agents, tumor suppressants, tissue and/or cell engineering agents, imaging contrast agents, tissue staining agents, nutrients, and mixtures thereof.

9. The apparatus as recited in claim 1, wherein said apparatus is a direct mechanical ventricular assistance apparatus.

10. The apparatus as recited in claim 9, wherein said direct mechanical ventricular assistance apparatus comprises a liner, and wherein said at least one membrane is formed in said liner.

11. The apparatus as recited in claim 10, wherein said therapeutic agent is impregnated in said liner.

12. The apparatus as recited in claim 10, wherein said liner further comprises an impermeable film separated from said at least one membrane by a gap, and wherein said therapeutic agent is contained in said gap.

13. The apparatus as recited in claim 10, wherein said liner is detachable from said apparatus.

14. The apparatus as recited in claim 10, wherein said therapeutic agent is selected from the group consisting of anti-inflammatory agents, gene therapy agents, gene transfer agents, stem cells, chemo-attractants, cell regeneration agents, ventricular remodeling agents, anti-infection agents, tumor suppressants, tissue and/or cell engineering agents, imaging contrast agents, tissue staining agents, nutrients, and mixtures thereof.

15. The apparatus as recited in claim 9, wherein said direct mechanical ventricular assistance apparatus comprises a seal, and wherein said at least one membrane is formed in said seal.

16. The apparatus as recited in claim 15, wherein said therapeutic agent is impregnated in said seal.

17. The apparatus as recited in claim 15, wherein said seal further comprises a cavity, and wherein said therapeutic agent is contained in said cavity.

18. The apparatus as recited in claim 15, wherein said seal is detachable from said apparatus.

19. The apparatus as recited in claim 18, wherein said therapeutic agent is selected from the group consisting of anti-inflammatory agents, gene therapy agents, gene transfer agents, stem cells, chemo-attractants, cell regeneration agents, ventricular remodeling agents, anti-infection agents, tumor suppressants, tissue and/or cell engineering agents, imaging contrast agents, tissue staining agents, nutrients, and mixtures thereof.

20. The apparatus as recited in claim 15, wherein said therapeutic agent is selected from the group consisting of anti-inflammatory agents, gene therapy agents, gene transfer agents, stem cells, chemo-attractants, cell regeneration agents, ventricular remodeling agents, anti-infection agents, tumor suppressants, tissue and/or cell engineering agents, imaging contrast agents, tissue staining agents, nutrients, and mixtures thereof.

21. The apparatus as recited in claim 9, wherein said direct mechanical ventricular assistance apparatus comprises at least one sensor measuring at least one parameter.

22. The apparatus as recited in claim 21, wherein said direct mechanical ventricular assistance apparatus comprises a liner, and wherein said at least one membrane is formed in said liner.

23. The apparatus as recited in claim 21, wherein said direct mechanical ventricular assistance apparatus further comprises a seal, and wherein said at least one membrane is formed in said seal.

24. The apparatus as recited in claim 1, further comprising a second membrane comprised of means to deliver said agent to said desired tissue, said second membrane being in contact with at least a part of said desired tissue to be treated.

25. The apparatus as recited in claim 24, wherein the first of said membranes is formed as a liner, and the second of said membranes is formed as a seal.

26. The apparatus as recited in claim 25, wherein said therapeutic agent is selected from the group consisting of anti-inflammatory agents, gene therapy agents, gene transfer agents, stem cells, chemo-attractants, cell regeneration agents, ventricular remodeling agents, anti-infection agents, tumor suppressants, tissue and/or cell engineering agents, imaging contrast agents, tissue staining agents, nutrients, and mixtures thereof.