Methods, systems, and computer program products for analyzing cardiovascular sounds using eigen functions
First Claim
1. A non-invasive method of detecting arterial disease in vivo, comprising:
- obtaining acoustic signals from one or more sensors held on an external body region proximate at least one artery;
generating a complex frequency grid of frequencies and associated lifetimes of the obtained acoustic signals;
providing a predictive model of complex frequencies associated with peak-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with early stage arterial disease;
providing a predictive model of complex frequencies associated with line-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with later stage arterial disease an/or the thickening of arterial junctions; and
determining whether peak and/or line-perturbation acoustic signals of the predictive models are present to detect whether the subject has arterial disease.
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Accused Products
Abstract
Non-invasive methods for detecting arterial disease in vivo include obtaining acoustic signals from a sensor held on an external body region proximate an artery. A complex frequency grid of frequencies and associated lifetimes of the obtained acoustic signals is generated. A predictive model of complex frequencies associated with peak-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with early stage arterial disease is provided. A predictive model of complex frequencies associated with line-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with later stage arterial disease and thickening of arterial junctions is also provided. It is determined whether peak and/or line-perturbation acoustic signals of the predictive models are present to detect whether the subject has arterial disease.
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Citations
27 Claims
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1. A non-invasive method of detecting arterial disease in vivo, comprising:
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obtaining acoustic signals from one or more sensors held on an external body region proximate at least one artery;
generating a complex frequency grid of frequencies and associated lifetimes of the obtained acoustic signals;
providing a predictive model of complex frequencies associated with peak-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with early stage arterial disease;
providing a predictive model of complex frequencies associated with line-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with later stage arterial disease an/or the thickening of arterial junctions; and
determining whether peak and/or line-perturbation acoustic signals of the predictive models are present to detect whether the subject has arterial disease. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A non-invasive system for detecting arterial disease in vivo, comprising:
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one or more acoustic signal sensors configured for positioning on an external body region proximate at least one artery for obtaining acoustic signals;
a complex frequency data point generator module configured to generate a complex frequency grid of frequencies and associated lifetimes using the obtained acoustic signals;
a peak-perturbation module in communication with the complex frequency data point generator comprising a predictive model of complex frequencies associated with peak-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with early stage arterial disease;
a line-perturbation module in communication with the complex frequency data point generator comprising a predictive model of complex frequencies associated with line-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with later stage arterial disease and/or acoustic signals attributed to junction perturbations where arteries split in vivo; and
the peak-perturbation module and the line-perturbation module being configured for determining whether peak and/or line-perturbation acoustic signals of the predictive models are present to detect whether the subject has arterial disease.
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27. A computer program product for detecting arterial disease in vivo, the computer program product comprising program code embodied in a computer-readable storage medium, the computer program code comprising:
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computer program code that is configured to obtain acoustic signals from one or more sensors held on an external body region proximate at least one artery;
computer program code that is configured to generate a complex frequency grid of frequencies and associated lifetimes of the obtained acoustic signals;
computer program code that is configured to provide a predictive model of complex frequencies associated with peak-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with early stage arterial disease;
computer program code that is configured to provide a predictive model of complex frequencies associated with line-perturbation acoustic signals attributed to boundary perturbations in vivo that occur with later stage arterial disease an/or the thickening of arterial junctions; and
computer program code that is configured to determine whether peak and/or line-perturbation acoustic signals of the predictive models are present to detect whether the subject has arterial disease.
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Specification