Plug for use in left atrial appendage
First Claim
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1. A device comprising a plug for blocking part or all of a left atrial appendage (LAA), the plug having a monolithic construction and having a proximal end and a distal end, the plug tapering from a larger diameter at the proximal end to a smaller diameter at the distal end.
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Abstract
A plug or insert occludes the left atrial appendage (LAA), thus preventing blood from entering. The plug is formed in one piece without separately movable parts, and may be monolithic. A drug coating can be provided, with or without a plug.
152 Citations
22 Claims
- 1. A device comprising a plug for blocking part or all of a left atrial appendage (LAA), the plug having a monolithic construction and having a proximal end and a distal end, the plug tapering from a larger diameter at the proximal end to a smaller diameter at the distal end.
- 13. A plug comprising a substantially axisymmetric body comprising a compressible material selected from the group consisting of porous-surface silicone, polyvinyl alcohol, collagen, and polyurethane foam, wherein the plug in compressed form has a maximum diameter of less than 5 mm and wherein the plug in non-compressed form partially or wholly fills an interior volume of a left atrial appendage (LAA) of a heart.
- 17. A method of locally releasing one or more agents into the left atrial appendage (LAA) of a heart of a subject, the method comprising depositing a means for delivery of one or more agents on an interior wall of the LAA, and releasing the one or more agents into the interior of the LAA.
Specification