Expandable medical device with openings for delivery of multiple beneficial agents

• US 20050234544A1
• Filed: 06/22/2005
• Published: 10/20/2005
• Est. Priority Date: 09/20/2002
• Status: Abandoned Application

• Current Assignee: Innovational Holdings, LLC
• Original Assignee: Conor Medsystems Incorporated
• Inventors: Shanley, John F.
• Application Number:
  US11/165,472
• Publication Number:
  US 20050234544A1
• Time in Patent Office: Days
• US Class Current: 623/1.420
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91508 the meander having a difference in amplitude along the band
• CPC Class Codes: A61F 2002/91516 the meander having a change in frequency along the band
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2250/0035 differing in release or diffusion time
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents can be loaded into different openings within the struts for delivery to the tissue. For treatment of specified conditions such as edge effect restenosis or for improved spacial distribution of the delivered beneficial agent, different beneficial agents are loaded into different openings in the device in a predefined pattern. The different beneficial agents may include one or more different drugs, the same drugs in different concentrations or with different erosion rates, or different forms of the same drug.

Claims

1-30. -30. (canceled)

31. An expandable medical device for delivery of a beneficial agent, the device comprising:

a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter;

a plurality of openings formed in a regular pattern throughout the substantially cylindrical device and configured to form reservoirs for a beneficial agent;

wherein a first portion of the plurality of openings are filled with a beneficial agent; and

wherein a second portion of the plurality of openings formed at one end of the substantially cylindrical device are left open.

32. The device of claim 31, wherein the openings left open provide a cool end to prevent double-dosing of the beneficial agent when overlapping stents are used.

33. The device of claim 31, wherein the beneficial agent is paclitaxel.

34. The device of claim 31, wherein the beneficial agent is rapamycin.

35. The device of claim 31, wherein beneficial agent is an agent for reducing restenosis.

36. A method of reducing restenosis in a body passageway, the method comprising:

positioning a first tissue supporting device in a body passageway to support the tissue, the tissue supporting device containing a beneficial agent selected to reduce restenosis, the beneficial agent provided in openings in the device; and

positioning a second tissue supporting device in the body passageway partially overlapping the first tissue supporting device, wherein the second tissue supporting device contains the beneficial agent in selected openings with some of the openings on an overlapping portion of the second tissue supporting device left open.

37. The device of claim 36, wherein the openings left open provide a cool end to prevent double-dosing of the beneficial agent when overlapping stents are used.

38. The device of claim 36, wherein the beneficial agent is paclitaxel.

39. The device of claim 36, wherein the beneficial agent is rapamycin.

40. The device of claim 36, wherein beneficial agent is an agent for reducing restenosis.