Zinc salt compositions for the prevention of dermal and mucosal irritation

• US 20050238602A1
• Filed: 01/07/2005
• Published: 10/27/2005
• Est. Priority Date: 02/07/2002
• Status: Active Grant

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta M., Shintre, Milind, Gaonkar, Trupti, Caraos, Lauserpina, Geraldo, Ingrid
• Granted Patent: US 7,435,429 B2
• Time in Patent Office: Days
• US Class Current: 424/70.110
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/315 Zinc compounds
• CPC Class Codes: A61K 8/36 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/361 Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

The present invention provides for compositions and methods that may offer protection from irritants, as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions comprising two or more water-soluble zinc salts in low concentrations.

Claims

1. A surgical hand wash, comprising:

(i) two or more organic salts of zinc, each having a molar solubility in water of between about 0.17 and 1.64 moles/liter, wherein said organic salts of zinc in total are present at a combined concentration of between about 0.1 and 0.5 percent (weight/weight);

(ii) farnesol at a concentration of between about 0.3 and 1.0 percent (weight/weight);

(iii) panthenol at a concentration of between about 0.2 and 5 percent (weight/weight); and

(iv) a quaternary ammonium compound and a biguanide, wherein the total concentration of quaternary ammonium compound and biguainde is between about 0.05 and 2.0 percent (weight/weight).

2. The surgical hand wash of claim 1, wherein the organic salts of zinc are zinc gluconate, present at a concentration of between about 0.10-0.25 percent (weight/weight) and zinc lactate, present at a concentration of about between about 0.10-0.25 percent (weight/weight).

3. A disinfectant soap, comprising:

(i) two or more organic salts of zinc, each having a molar solubility in water of between about 0.17 and 1.64 moles/liter, wherein said organic salts of zinc in total are present at a combined concentration of between about 0.1 and 0.5 percent (weight/weight);

(ii) farnesol at a concentration of between about 0.3 and 1.0 percent (weight/weight);

(iii) panthenol at a concentration of between about 0.2 and 5 percent (weight/weight); and

(iv) a quaternary ammonium compound and a second antimicrobial agent selected from the group consisting of a biguanide and a chlorinated phenol, wherein the total concentration of quaternary ammonium compound and second antimicrobial agent is between about 0.05 and 2.0 percent (weight/weight).

4. The disinfectant soap of claim 3, wherein the organic salts of zinc are zinc gluconate, present at a concentration of between about 0.10-0.25 percent (weight/weight) and zinc lactate, present at a concentration of about between about 0.10-0.25 percent (weight/weight).

5. The disinfectant soap of claim 3, further comprising phenoxyethanol at a concentration of between about 0.3 and 1 percent (weight/weight).

6. The disinfectant soap of claim 4, further comprising phenoxyethanol at a concentration of between about 0.3 and 1 percent (weight/weight).