Process for the production of dendritic trimesic acid triamides

• US 20050238615A1
• Filed: 12/16/2004
• Published: 10/27/2005
• Est. Priority Date: 12/16/2003
• Status: Active Grant

• Current Assignee: Bayer Schering Pharma AG (Bayer AG)
• Original Assignee: Bayer Schering Pharma AG (Bayer AG)
• Inventors: Platzek, Johannes, Graske, Klaus-Dieter
• Granted Patent: US 7,199,268 B2
• Time in Patent Office: Days
• US Class Current: 424/78.80
• CPC Class Codes: C07C 269/06 by reactions not involving the formation of carbamate groups
• CPC Class Codes: C07C 271/22 to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• CPC Class Codes: C07K 7/02 Linear peptides containing at least one abnormal peptide link

Abstract

A new process for the production of dendritic trimesic acid triamides is described.

Claims

1. Process for the production of compounds of general formula I

2. Process according to claim 1, wherein THF, 1-methyl-THF, tetrahydropyran, dichloromethane, 1,2-dimethoxyethane, dioxane, acetonitrile, propionitrile or chloroform is used as a non-protic solvent.

3. Process according to claim 1, wherein an organic base is used as an acid trap.

4. Process according to claim 1, wherein an inorganic base is used as an acid trap.

5. Process according to claim 3, wherein triethylamine, Hü

nig base, tributylamine, pyridine or lutidine is used as an acid trap.

6. Process according to claim 4, wherein sodium carbonate, potassium carbonate or lithium carbonate is used as an acid trap.

7. Process according to claim 1, wherein the operation is performed at temperatures of 50-80°

C.

8. Process according to claim 1, wherein the reaction is performed within 0.5 to 2.5 hours.

10. Use of the compounds of general formula I according to claim 1 for the production of Gadomer.

9. Compounds of general formula III