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Diagnosing predisposition to fat deposition and associated conditions

  • US 20050239077A1
  • Filed: 06/27/2003
  • Published: 10/27/2005
  • Est. Priority Date: 06/27/2002
  • Status: Abandoned Application
First Claim
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1. A method for diagnosing a predisposition to fat deposition in a subject, which comprises detecting the presence or absence of a polymorphic variation associated with fat deposition at a polymorphic site in a PLA2G1B nucleotide sequence in a nucleic acid sample from a subject, wherein the PLA2G1B nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of:

  • (a) the nucleotide sequence of SEQ ID NO;

    1;

    (b) a nucleotide sequence which encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO;

    2;

    (c) a nucleotide sequence which encodes a polypeptide that is 90% identical to the amino acid sequence of SEQ ID NO;

    2; and

    (d) a fragment of a nucleotide sequence of (a), (b), or (c) comprising the polymorphic site;

    whereby the presence of the polymorphic variation is indicative of a predisposition to fat deposition in the subject.

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