Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles

• US 20050239508A1
• Filed: 04/23/2004
• Published: 10/27/2005
• Est. Priority Date: 04/23/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Schwarz, Marlene C., Richard, Robert E., Zhong, Sheng-Ping
• Granted Patent: US 9,498,563 B2
• Time in Patent Office: Days
• US Class Current: 455/562.100
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Medical articles, such as drug-releasing patches or implantable or insertable medical devices, which are made up of a medical article substrate and a therapeutic-agent-containing region. The therapeutic-agent-containing region is made up of (i) a water-dispersible therapeutic agent therapeutic agent and (ii) coalesced polymer particles supplied by an aqueous dispersion. Also described are methods of forming such medical articles, and methods of releasing a therapeutic agent within a patient using such medical articles.

Claims

1. A medical article comprising a medical article substrate and a therapeutic-agent-containing region disposed over said substrate, wherein said therapeutic-agent-containing region comprises (i) a water-dispersible therapeutic agent and (ii) coalesced polymer particles of an aqueous dispersion

2. The medical article of claim 1, wherein said aqueous dispersion is a true latex.

3. The medical article of claim 1, wherein said aqueous dispersion is a pseudolatex.

4. The medical article of claim 1, wherein said polymer particles comprise a block copolymer comprising a poly(alkylene) chain and a poly(vinyl aromatic) chain.

5. The medical article of claim 4, wherein said polymer particles comprise a block copolymer comprising a poly(isobutylene) chain and a poly(styrene) chain.

6. The medical article of claim 4, wherein said polymer particles comprise a block copolymer comprising a poly(butadiene/butylene) chain and a poly(styrene) chain.

7. The medical article of claim 1, wherein said polymer particles comprise a polyurethane.

8. The medical article of claim 1, wherein said polymer particles comprise an acrylic acid polymer or copolymer.

9. The medical article of claim 1, wherein said polymer particles comprise a dialkylsiloxane polymer or copolymer.

10. The medical article of claim 1, wherein said polymer particles comprise a polymer that comprises a hydrophilic portion and a hydrophobic portion.

11. The medical article of claim 1, wherein said coalesced polymer particles do not comprise a surfactant.

12. The medical article of claim 1, wherein said polymer particles comprise a crosslinked polymer.

13. The medical article of claim 1, wherein said polymer particles do not comprise a crosslinked polymer.

14. The medical article of claim 1, wherein said polymer particles comprise a plurality of polymer species.

15. The medical article of claim 1, wherein said therapeutic-agent-containing region comprises a plurality of water-dispersible therapeutic agent species.

16. The medical article of claim 1, wherein said therapeutic-agent-containing region is in the form of layer disposed over a portion of the medical article substrate.

17. The medical article of claim 1, wherein said theraputic-agent-containing region is in the form of layer disposed over the entirety of the medical article substrate surface.

18. The medical article of claim 1, wherein said medical article is implantable or insertable into a human body.

19. The medical article of claim 18, wherein said water-dispersible therapeutic agent is selected from an anti-thrombotic agent, an anti-proliferative agent, an anti-inflammatory agent, an anti-migratory agent, an agent affecting extracellular matrix production and organization, an anti-neoplastic agent, an anti-mitotic agent, an anesthetic agent, an anti-coagulant, a vascular cell growth promoter, a vascular cell growth inhibitor, a cholesterol-lowering agent, a vasodilating agent, and an agent that interferes with endogenous vasoactive mechanisms.

20. The medical article of claim 18, wherein said medical article is a medical device is selected from a catheter, a guide wire, a balloon, a filter, a stent, a stent graft, a vascular graft, a vascular patch and a shunt.

21. The medical article of claim 18, wherein said implantable or insertable medical device is adapted for implantation or insertion into the coronary or peripheral vasculature.

22. The medical article of claim 18, wherein said implantable or insertable medical device is adapted for implantation or insertion into the esophagus, trachea, colon, biliary tract, urinary tract, prostate or brain.

23. The medical article of claim 1, wherein said water-dispersible therapeutic agent is a water-soluble therapeutic agent