Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
First Claim
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1. A method for treating obesity or an obesity-related disorder, the method comprising:
- (a) diagnosing a subject in need of treatment for obesity or an obesity-related disorder; and
(b) increasing either the amount of or the activity of a Fiaf polypeptide in the subject.
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Abstract
The invention provides compositions and methods to modulate fat storage and weight loss in a subject. In certain aspects of the invention, fat storage (adiposity) and weight loss is modulated by altering the subject'"'"'s gastrointestinal microbiota population. In other aspects of the invention, fat storage and weight loss is modulated by altering the amount of or the activity of the protein, fasting-induced adipocyte factor, in the subject.
81 Citations
42 Claims
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1. A method for treating obesity or an obesity-related disorder, the method comprising:
- (a) diagnosing a subject in need of treatment for obesity or an obesity-related disorder; and
(b) increasing either the amount of or the activity of a Fiaf polypeptide in the subject. - View Dependent Claims (2, 3, 4, 5)
- (a) diagnosing a subject in need of treatment for obesity or an obesity-related disorder; and
- 6. A method for decreasing body fat or for promoting weight loss in a subject, the method comprising increasing either the amount of or the activity of a Fiaf polypeptide in the subject.
- 10. A method for decreasing body fat or for promoting weight loss in a subject, the method comprising altering the microbiota population in the subject'"'"'s gastrointestinal tract such that at least one microbial-mediated signaling pathway in the subject that regulates energy storage is either stimulated or substantially inhibited, whereby stimulating or inhibiting the signaling pathway causes a decrease in body fat or promotes weight loss in the subject.
- 22. A method for decreasing body fat or for promoting weight loss in a subject, the method comprising altering the microbiota population in the subject'"'"'s gastrointestinal tract such that microbial-mediated transcriptional suppression of a lipoprotein lipase inhibitor in the subject is decreased.
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30. A method for treating obesity or an obesity-related disorder, the method comprising:
- (a) diagnosing a subject in need of treatment for obesity or an obesity-related disorder; and
(b) altering the microbiota population in the subject'"'"'s gastrointestinal tract such that microbial-mediated transcriptional suppression of a lipoprotein lipase inhibitor in the subject is decreased. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38)
- (a) diagnosing a subject in need of treatment for obesity or an obesity-related disorder; and
- 39. A composition for decreasing body fat or for promoting weight loss, the composition comprising a Fiaf polypeptide and an agent that alters the microbiota population in a subject'"'"'s gastrointestinal tract such that microbial-mediated transcriptional suppression of a lipoprotein lipase inhibitor in the subject is decreased.
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42. A biomarker for use in predicting whether a subject is at risk for becoming obese or suffering from an obesity-related condition, the biomarker comprising the amount of circulating Fiaf polypeptide.
Specification