System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device

• US 20050240240A1
• Filed: 04/21/2004
• Published: 10/27/2005
• Est. Priority Date: 04/21/2004
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Benser, Michael, Park, Euljoon
• Granted Patent: US 7,245,971 B2
• Time in Patent Office: Days
• US Class Current: 607/42
• CPC Class Codes: A61N 1/3601 of respiratory organs

Abstract

Techniques are provided for treating periodic breathing, such as Cheyne-Stokes Respiration, using an implantable medical system. In one technique, diaphragmatic stimulation is delivered during a hyperpnea phase of periodic breathing via electrical stimulation of the phrenic nerves. Diaphragmatic stimulation is synchronized with intrinsic inspiration so as to increase the amplitude of diaphragmatic contraction during inspiration. This tends to decrease intrathoracic pressure leading to occlusion of the respiratory airway. Occlusion reduces actual ventilation during hyperpnea, thus reducing the cyclic blood chemistry imbalance that sustains periodic breathing so as to either mitigate periodic breathing or eliminate it completely. In another technique, respiration is instead inhibited during the hyperpnea phase of periodic breathing by blocking phrenic nerve signals to the extent necessary to reduce ventilation to terminate periodic breathing or at least mitigate its severity. Techniques are also described for controlling the type of therapy applied in response to periodic breathing.

Claims

1. A method for delivering therapy in response to periodic breathing within a patient using an implantable medical system, the method comprising:

detecting a period of hyperpnea; and

selectively delivering diaphragmatic stimulation during the period of hyperpnea.

2. The method of claim 1 wherein the diaphragmatic stimulation is delivered by an amount sufficient to cause upper airway occlusion such that actual ventilation is reduced during the periods of hyperpnea so as to mitigate periodic breathing.

3. The method of claim 1 wherein the diaphragmatic stimulation is synchronized with intrinsic respiration occurring during hyperpnea.

4. The method of claim 1 wherein the diaphragmatic stimulation is delivered in response to periods of hyperpnea occurring during Cheyne-Stokes Respiration.

5. The method of claim 1 wherein an implantable nerve stimulator is provided and wherein delivering diaphragmatic stimulation during hyperpnea is performed by delivering electrical nerve stimulation to the phrenic nerves of the patient using the implantable nerve stimulator.

6. The method of claim 1 further comprising determining whether frank apnea is occurring during the hypopnea periods of the periodic breathing and wherein diaphragmatic stimulation is delivered during the periods of hyperpnea only if frank apnea is found to occur during the during the hypopnea periods.

7. An implantable medical system for delivering therapy in response to periodic breathing within a patient, the system comprising:

a periodic breathing detection system operative to detect episodes of periodic breathing and to identify periods of hyperpnea therein; and

a hyperpnea-based diaphragmatic stimulation system operative to selectively deliver diaphragmatic stimulation during the periods of hyperpnea.

8. The implantable medical system of claim 7 wherein the diaphragmatic stimulation system is operative to deliver diaphragmatic stimulation in an amount sufficient to cause upper airway occlusion.

9. The implantable medical system of claim 7 wherein the diaphragmatic stimulation system is operative to synchronize the diaphragmatic stimulation with intrinsic respiration.

10. The implantable medical system of claim 7 wherein the periodic breathing detection system is operative to detect Cheyne-Stokes Respiration, and wherein the diaphragmatic stimulation system is operative to deliver diaphragmatic stimulation in response to periods of hyperpnea occurring during Cheyne-Stokes Respiration.

11. The implantable medical system of claim 7 wherein the diaphragmatic stimulation system comprises an implantable nerve stimulator that is operative to deliver electrical nerve stimulation to the phrenic nerves of the patient.

12. An implantable medical system for delivering therapy in response to periodic breathing within a patient, the system comprising:

a periodic breathing detection system operative to detect episodes of periodic breathing and to identify periods of hyperpnea and hypopnea therein;

a periodic breathing severity evaluation system operative to detect episodes of frank apnea, if any, occurring during the periods of hypopnea;

a hyperpnea-based diaphragmatic stimulation system operative to selectively deliver diaphragmatic stimulation during the periods of hyperpnea if frank apnea is found to occur during the periods of hypopnea; and

a hypopnea-based diaphragmatic stimulation system operative to selectively deliver diaphragmatic stimulation during the periods of hypopnea if frank apnea is not found to occur during the periods of hypopnea.

13. The implantable medical system of claim 12 wherein the diaphragmatic stimulation system is operative to deliver diaphragmatic stimulation in an amount sufficient to cause upper airway occlusion.

14. The implantable medical system of claim 12 wherein the diaphragmatic stimulation system is operative to synchronize the diaphragmatic stimulation with intrinsic respiration.

15. The implantable medical system of claim 12 wherein the periodic breathing detection system is operative to detect Cheyne-Stokes Respiration, and wherein the diaphragmatic stimulation system is operative to deliver diaphragmatic stimulation in response to periods of hyperpnea occurring during Cheyne-Stokes Respiration.

16. The implantable medical system of claim 12 wherein the diaphragmatic stimulation system comprises an implantable nerve stimulator that is operative to deliver electrical nerve stimulation to the phrenic nerves of the patient.