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Methods and systems for differential clustering

  • US 20050240357A1
  • Filed: 04/26/2004
  • Published: 10/27/2005
  • Est. Priority Date: 04/26/2004
  • Status: Abandoned Application
First Claim
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1. A high throughput method of identifying genes that are potentially functionally variant, said method comprising the steps of:

  • providing gene expression values for a plurality of genes for each of a number of tissues wherein the expression values are given for the same genes in each of the number of tissues;

    dividing the number of tissues into at least first and second groups of tissues;

    generating a gene expression response profile for each gene representative of all gene expression values for that gene across all tissue samples in the first group;

    clustering the gene expression response profiles generated with respect to the first group;

    generating a gene expression response profile for each gene representative of all gene expression values for that gene across all tissue samples in the second group;

    clustering the gene expression response profiles generated with respect to the second group;

    comparing gene expression response profile members in clusters generated with respect to the first group with gene expression response profile members in clusters generated with respect to the second group and identifying those members that change cluster membership in the second group relative to the first group;

    statistically calculating whether the move of a member from membership in a first cluster to membership in a second cluster is significant relative to the variance within the first and second clusters and the variance between the first and second clusters; and

    if the move is calculated to be significant, identifying the gene represented by the member as a potential functionally variant gene.

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