Composition and method for preparing biocompatible surfaces
First Claim
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1. A medical article having a bioactive agent-releasing coating having heparin activity, the coating comprising:
- (a) a first coated layer comprising a bioactive agent; and
(b) a second coated layer formed from a second coating composition comprising heparin, photoreactive groups, and a polymeric material, wherein the second coating composition is irradiated prior to being disposed to form the second coated layer.
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Abstract
The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
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Citations
22 Claims
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1. A medical article having a bioactive agent-releasing coating having heparin activity, the coating comprising:
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(a) a first coated layer comprising a bioactive agent; and
(b) a second coated layer formed from a second coating composition comprising heparin, photoreactive groups, and a polymeric material, wherein the second coating composition is irradiated prior to being disposed to form the second coated layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for preparing a medical article having a bioactive agent-releasing coating with heparin activity, comprising the steps of:
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(a) providing a medical article having a first coated layer comprising a bioactive agent; and
(b) irradiating a composition comprising heparin, photoreactive groups, and polymeric material to activate the photoreactive groups;
(c) after step (b), disposing the irradiated composition on the first coated layer.
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21. A medical article having a bioactive agent-releasing coating having heparin activity of 10 mU/cm2 or greater, the coating comprising:
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(a) biostable or biodegradable polymer;
(b) bioactive agent;
(c) heparin, and (d) photoreactive groups, wherein the photoreactive groups are activated prior to being placed in contact with the medical article.
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22. A medical article having a bioactive agent-releasing coating comprising:
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(a) hydrophobic polymer (b) bioactive agent;
(c) heparin;
(d) photoreactive groups; and
(e) a component selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, polyethylene glycol sulfonates, fatty quaternary amines, fatty sulfonates, fatty acids, dextran, dextrin, and cyclodextrin.
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Specification