Controlled release drug delivery systems and methods for treatment of an eye
First Claim
1. A drug delivery system for controlled drug release into an eye comprising:
- an element sized and adapted for placement into an eye, said element including a therapeutic component and a matrix component, the therapeutic component being located in combination with the matrix component, the element having at least one of a controlled porosity and a controlled roughness effective in controlling a release rate of the therapeutic component from the element into an eye in which the element is placed.
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Abstract
Systems and method are provided for treatment of an eye. The systems generally include controlled release implantable elements including a therapeutic component and a substantially inactive matrix component. The systems include such elements having controlled porosities and/or controlled surface roughness. The elements are typically bioerodible and structured to be implantable into a desired location of an eye to provide delivery of the therapeutic component to the eye. The elements exhibit relatively more controllable, more predictable, drug release rate profile in comparison to substantially identical elements without such controlled porosities and/or surface roughness.
175 Citations
35 Claims
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1. A drug delivery system for controlled drug release into an eye comprising:
an element sized and adapted for placement into an eye, said element including a therapeutic component and a matrix component, the therapeutic component being located in combination with the matrix component, the element having at least one of a controlled porosity and a controlled roughness effective in controlling a release rate of the therapeutic component from the element into an eye in which the element is placed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of making a drug delivery system for modified drug delivery into an eye comprising:
forming an element sized and adapted for placement into an eye, said element including a therapeutic component and a matrix component, the therapeutic component being located in the matrix component, wherein the forming step is conducted at conditions effective in controlling at least one of a porosity of the matrix component and a roughness of the matrix component, in order to provide a controlled release rate of the therapeutic component from the element into an eye in which the element is placed. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
Specification