Drug delivery systems and methods for treatment of an eye
First Claim
1. A drug delivery system for modified drug release into an eye comprising:
- an element sized and adapted for placement into an eye, said element including a core containing a therapeutic component, a first layer component located on a first side of the core, and a second layer component located on a substantially opposing second side of the core, wherein release of the therapeutic component from the core into the eye is reduced relative to a substantially identical element without the first and second layer components.
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Accused Products
Abstract
Systems and methods are provided for treatment of an eye. The systems generally include controlled, delayed and or sustained release bioerodible implantable elements having multiple layers of different materials and/or different concentrations of materials. The elements generally include an inner layer, or core, including a therapeutic agent, and one or more outer layers made of polymeric materials, for example substantially pure polymeric materials. The core may include a polymeric material combined with an active agent beneficial in treating a condition of an eye. The elements may be structured such that surfaces of the core are exposed to the physiological environment of the eye when initially implanted within the eye, or may be structured such that the core is entirely enclosed within the outer layers when initially implanted within the eye.
139 Citations
36 Claims
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1. A drug delivery system for modified drug release into an eye comprising:
- an element sized and adapted for placement into an eye, said element including a core containing a therapeutic component, a first layer component located on a first side of the core, and a second layer component located on a substantially opposing second side of the core, wherein release of the therapeutic component from the core into the eye is reduced relative to a substantially identical element without the first and second layer components.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27, 29, 30, 31, 32, 33, 34, 35, 36)
- 26. A drug delivery system for modified drug release into an eye comprising. an element sized and adapted for placement into an eye, said element including a core containing a steroid component, a first layer component located on a first side of the core and including a first polymeric material, and a second layer component located on a substantially opposing second side of the core and including a second polymeric material, wherein release of the steroid component from the core into the eye is reduced relative to a substantially identical element without the first and second layer components.
Specification