Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
First Claim
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1. A biodegradable intraocular implant comprising:
- an estradiol derivative and a biodegradable polymer matrix that is substantially free of a polyvinyl alcohol and that releases drug at a rate effective to sustain release of an amount of the estradiol derivative from the implant for at least about one week after the implant is placed in an eye.
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Abstract
Biocompatible intraocular implants include an anti-angiogenic agent, such as estradiol derivative or an estratopone and a biodegradable polymer that is effective to facilitate release of the anti-angiogenic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as angiogenisis, ocular tumors, and the like.
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Citations
50 Claims
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1. A biodegradable intraocular implant comprising:
an estradiol derivative and a biodegradable polymer matrix that is substantially free of a polyvinyl alcohol and that releases drug at a rate effective to sustain release of an amount of the estradiol derivative from the implant for at least about one week after the implant is placed in an eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A biodegradable intraocular implant comprising:
an estratopone and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the estratopone from the implant for at least about one week after the implant is placed in an eye. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method of making a biodegradable intraocular implant, comprising the step of:
- extruding a mixture of an estradiol derivative or an estratopone and a biodegradable polymer component to form a biodegradable material that degrades at a rate effective to sustain release of an amount of the estradiol derivative or an estratopone from the implant for at least about one week after the implant is placed in an eye.
- View Dependent Claims (36, 37, 38, 39, 40)
- 41. A method of treating an ocular condition characterized by undesirable angiogenisis in an eye of a patient, comprising the step of placing a biodegradable intraocular implant in an eye of the patient, the implant comprising (i) an estradiol derivative and a biodegradable polymer matrix substantially free of polyvinyl alcohol, or (ii) an estratopone and a biodegradable polymer matrix, wherein the implant degrades at a rate effective to sustain release of an amount of the estradiol derivative or estratopone from the implant effective to reduce angiogenisis in the eye of the patient.
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49. A biodegradable intraocular implant comprising:
an anti-angiogenic agent and a biodegradable polymer matrix that is substantially free of a polyvinyl alcohol and that releases drug at a rate effective to sustain release of an amount of the anti-angiogenic agent from the implant for at least about one week after the implant is placed in an eye.
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50. A biodegradable intraocular implant comprising:
anacortate and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the anacortate from the implant for at least about one week after the implant is placed in an eye.
Specification