Biodegradable intravitreal tyrosine kinase implants
First Claim
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1. A biodegradable intravitreal implant comprising:
- a tyrosine kinase inhibitor (TKI) and a biodegradable polymer, the implant releasing the TKI at a rate effective to sustain release of the TKI from the implant for at least about one week after the implant is placed in the vitreous of an eye.
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Abstract
Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.
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Citations
13 Claims
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1. A biodegradable intravitreal implant comprising:
a tyrosine kinase inhibitor (TKI) and a biodegradable polymer, the implant releasing the TKI at a rate effective to sustain release of the TKI from the implant for at least about one week after the implant is placed in the vitreous of an eye. - View Dependent Claims (2, 3, 4, 5)
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6. A method of making a biodegradable intravitreal implant, comprising the step of:
- extruding a mixture of a TKI and a biodegradable polymer to form a biodegradable implant that degrades at a rate effective to sustain release of an amount of the TKI from the implant for at least about one week after the implant is placed in the vitreous of an eye.
- View Dependent Claims (7, 8)
- 9. A method of treating an ocular condition of an eye of a patient, comprising the step of placing a biodegradable intraocular implant into the vitreous of an eye of the patient, the implant comprising a TKI and a biodegradable polymer, wherein the implant degrades at a rate effective to sustain release of an amount of the TKI from the implant effective to treat the ocular condition.
Specification