Modulation of transthyretin expression
First Claim
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1. An antisense compound 13 to 80 nucleobases in length targeted to a nucleic acid molecule encoding human transthyretin, wherein said compound inhibits the expression of human transthyretin mRNA by at least 10%.
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Abstract
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.
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Citations
18 Claims
- 1. An antisense compound 13 to 80 nucleobases in length targeted to a nucleic acid molecule encoding human transthyretin, wherein said compound inhibits the expression of human transthyretin mRNA by at least 10%.
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15. A method of screening for a modulator of human transthyretin, the method comprising the steps of:
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contacting a preferred target segment of a nucleic acid molecule encoding human transthyretin with one or more candidate modulators of human transthyretin, and identifying one or more modulators of human transthyretin expression which modulate the expression of human transthyretin. - View Dependent Claims (16)
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17. A diagnostic method for identifying a disease state comprising identifying the presence of human transthyretin in a sample using at least one of the primers comprising SEQ ID NOs 5 or 6, or the probe comprising SEQ ID NO:
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Specification