Use of IL-17 expression to predict skin inflammation; methods of treatment
First Claim
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1. A method of evaluating the propensity of a subject to develop an inflammatory skin disorder comprising:
- a) obtaining a sample of skin from the subject; and
b) quantifying the level of IL-17 expression in the sample.
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Abstract
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17 and/or IL-23.
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Citations
15 Claims
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1. A method of evaluating the propensity of a subject to develop an inflammatory skin disorder comprising:
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a) obtaining a sample of skin from the subject; and
b) quantifying the level of IL-17 expression in the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of preventing skin inflammation comprising administering to a subject exhibiting a propensity to develop skin inflammation:
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a) an antagonist of IL-17;
b) an antagonist of IL-23;
orc) an antagonist of IL-17 and an antagonist of IL-23. - View Dependent Claims (11, 12, 13, 14, 15)
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Specification