Method of using recombinant human antithrombin for neurocognitive disorders
First Claim
1. A method for the treatment of prophylaxis of a neurocognitive disorder experienced by a surgical patient comprising administering an effective amount of antithrombin.
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Abstract
The present invention provides for the production of recombinant human antithrombin (rhAT) for the treatment or prophylaxis of neurocognitive disorders typically associated with major surgical procedures. The recombinant processes of the current invention as well as more efficient methods of treatment, formulation and production have been developed to treat the incidence of neurocognitive problems associated with visuoconstruction, parieto-occipital watershed area injury, hypoperfusion, microemboli or other larger embolic factors and/or CABG procedures secondary to surgery.
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Citations
31 Claims
- 1. A method for the treatment of prophylaxis of a neurocognitive disorder experienced by a surgical patient comprising administering an effective amount of antithrombin.
- 17. A method of treating a neurocognitive disorder or other disease condition medically related to said neurocognitive disorder comprising administering to a mammal in need of such treatment a therapeutically effective amount of a human recombinant antithrombin (rhAT) or a prodrug thereof or a pharmaceutically acceptable salt of said compound or of said prodrug.
Specification