Non-invasive measurement of blood glucose using retinal imaging
First Claim
1. A method for use in the determination of blood glucose concentration of an individual comprising:
- projecting a first light into retina of an eye of the individual;
directing a second light into the retina;
detecting light reflected from the retina from the second light;
measuring a visual pigment regeneration rate in the retina using the light reflected from the retina; and
determining the blood glucose concentration using the visual pigment regeneration rate.
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Accused Products
Abstract
An apparatus carries out measurements of blood glucose in a repeatable, non-invasive manner by measurement of the rate of regeneration of retinal visual pigments, such as cone visual pigments. The rate of regeneration of visual pigments is dependent upon the blood glucose concentration, and by measuring the visual pigment regeneration rate, blood glucose concentration can be accurately determined. This apparatus exposes the retina to light of selected wavelengths in selected distributions and subsequently analyzes the reflection (as color or darkness) from a selected portion of the exposed region of the retina, preferably from the fovea.
23 Citations
71 Claims
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1. A method for use in the determination of blood glucose concentration of an individual comprising:
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projecting a first light into retina of an eye of the individual;
directing a second light into the retina;
detecting light reflected from the retina from the second light;
measuring a visual pigment regeneration rate in the retina using the light reflected from the retina; and
determining the blood glucose concentration using the visual pigment regeneration rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. An apparatus for determining blood glucose concentration in an individual, the apparatus comprising:
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a first light adapted to project a first light into retina of an eye of the individual;
a second light adapted to project a second light into the retina of the eye;
a light detector adapted to detect light reflected from the retina from projecting the second light; and
a processor with programmed instructions adapted to calculate the blood glucose concentration using the light reflected from the retina. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A device for optical measurement of blood glucose concentration in an individual in a noninvasive manner, the device comprising:
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a light projector adapted to project light into retina of the eye of an individual, the light having a wavelength that is absorbed by visual pigment in the retina of the eye;
a light detector adapted to detect light reflected from the retina of the eye; and
a processor with programmed instructions adapted to calculate the blood glucose concentration utilizing a measurement of the rate of regeneration of visual pigment in the retina. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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Specification