Biopolar virtual electrode for transurethral needle ablation

• US 20050245923A1
• Filed: 04/29/2004
• Published: 11/03/2005
• Est. Priority Date: 04/29/2004
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gerber, Martin T., Christopherson, Mark A., Woessner, Julie M.
• Application Number:
  US10/835,193
• Publication Number:
  US 20050245923A1
• Time in Patent Office: Days
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/1485 having a short rigid shaft for accessing the inner body through natural openings
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/143 multiple needles
• CPC Class Codes: A61B 2018/1472 for use with liquid electrolyte, e.g. virtual electrodes
• CPC Class Codes: A61B 2018/1475 Electrodes retractable in or deployable from a housing

Abstract

A device and method for transurethral needle ablation of prostate tissue to alleviate BPH uses bipolar ablation needles and a virtual electrode. To create the virtual electrode, a conductive fluid is delivered to the target site within the prostate tissue. Ablation energy is then delivered to the target tissue and the virtual electrode via a pair of bipolar ablation needles. The ablation energy flows between the bipolar ablation needles, throughout the virtual electrode and the prostate tissue to create ablation lesions within the prostate.

Claims

1. A method for performing transurethral needle ablation, comprising:

deploying first and second ablation needles to a target tissue site within a prostate of a male patient, wherein the first and second ablation needles form a bipolar electrode pair;

delivering an electrically conductive fluid to the target tissue site; and

delivering ablation energy to the target tissue via the bipolar ablation needles.

2. The method of claim 1, further comprising delivering the fluid via fluid delivery ports carried by at least one of the ablation needles.

3. The method of claim 1, further comprising delivering the fluid via a fluid delivery port at a distal tip of at least one of the ablation needles.

4. The method of claim 1, further comprising delivering the fluid via an annular space formed by at least one ablation needle and an outer tube concentric with the at least one ablation needle.

5. The method of claim 1, further comprising delivering the fluid via a fluid delivery tube.

6. The method of claim 1, further comprising delivering the fluid before the delivery of the ablation energy.

7. The method of claim 1, further comprising delivering the fluid during the delivery of the ablation energy.

8. The method of claim 1, further comprising stopping delivery of the ablation energy, and delivering the fluid after stopping delivery of the ablation energy.

9. The method of claim 1, wherein the ablation energy includes electrical current selected to kill cells within the prostate.

10. The method of claim 1, wherein the fluid includes at least one of an anesthetic agent, an antiseptic, or an anti-inflammatory.

11. The method of claim 1, wherein delivering the electrically conductive fluid includes creating a virtual electrode within the prostate.

12. The method of claim 1, wherein delivering ablation energy comprises delivering an radio frequency ablation current that flows between the bipolar ablation needles.

13. The method of claim 1, further comprising penetrating a wall of a urethra of the patient with the bipolar ablation needles, extending the ablation needles into the prostate, delivering the fluid to the prostate via at least one of the ablation needles, and delivering the ablation energy to the prostate via the ablation needles.

14. The method of claim 1, wherein the fluid comprises saline.

15. The method of claim 14, wherein the saline comprises one of isotonic and hypertonic saline.

16. The method of claim 1, wherein the fluid is a gel having conductive particles suspended therein.

17. The method of claim 1, wherein the fluid includes one of NaCl (sodium chloride), CaCl₂ (calcium chloride), MgCl₃ (magnesium chloride), KCl (Potassium chloride), Na₂SO₃ (sodium sulfate), CaSO₄ (calcium sulfate), MgSO₄ (magnesium sulfate), Na₂HPO₄ (sodium hydrogen phosphate), Mg₃(PO₄)₂ (magnesium phosphate tribasic), NaHCO₃ (sodium bicarbonate), CaCO₃ (calcium carbonate), MgCO₃ (magnesium carbonate) or Ringer'"'"'s solution.

18. The method of claim 1 wherein deploying a set of bipolar ablation needles further includes deploying the bipolar ablation needles such that a distance between needle tips is approximately 1±

0.5 centimeters.

19. A transurethral ablation system comprising:

a transurethral catheter;

a first ablation needle extendable from the catheter to penetrate a prostate of a patient;

a second ablation needle extendable from the catheter to penetrate a prostate of a patient, wherein the first and second ablation needles form a bipolar electrode pair;

a fluid delivery conduit extending within the catheter;

a fluid delivery device to deliver fluid to the prostate via the fluid delivery conduit; and

an ablation energy generator to deliver ablation energy to the prostate via the first and second ablation needles and the fluid.

20. The system of claim 19, further comprising a fluid delivery port formed in at least one of the bipolar ablation needles and coupled to the fluid delivery conduit.

21. The system of claim 19, wherein the fluid delivery device delivers an electrically conductive fluid to the prostate.

22. The system of claim 21, wherein delivery of the electrically conductive fluid creates a virtual electrode within the prostate.

23. The system of claim 19, wherein the ablation energy and the fluid are both delivered to the prostate via the first and second ablation needles.

24. The system of claim 19, wherein the fluid delivery conduit includes a fluid delivery port in at least one of the bipolar ablation needles.

25. The system of claim 19, wherein the fluid delivery conduit includes fluid delivery ports in both of the bipolar ablation needles.

26. The system of claim 25, wherein the fluid delivery conduit is connected to supply the fluid to both bipolar ablation needles.

27. The system of claim 25, wherein the fluid delivery conduit includes first and second fluid delivery conduits, each of the conduits corresponding to one of the first and second bipolar ablation needles, and wherein each of the first and second fluid delivery conduits are connected to supply the fluid to its respective one of the first and second bipolar ablation needles.

28. The system of claim 27, wherein the fluid delivery device includes first and second fluid delivery devices connected to deliver fluid to the first and second fluid delivery conduits, respectively.

29. The system of claim 19, wherein the ablation energy is a current that flows between the first and second ablation needles.

30. The system of claim 19, further including fluid delivery ports carried by at least one of the ablation needles.

31. The system of claim 19, further including a fluid delivery port at the distal tip of at least one of the ablation needles.

32. The system of claim 19, further including an annular space for delivering the fluid formed by at least one of the ablation needles and an outer tube concentric with the at least one ablation needle.

33. The system of claim 19, further including a fluid delivery tube.

34. The system of claim 19, wherein the fluid includes saline.

35. The system of claim 34, wherein the fluid includes at least one of isotonic and hypertonic saline.

36. The system of claim 19, wherein the fluid includes at least one of an anesthetic, an antiseptic, an anti-inflammatory or a vaso-constrictor.

37. The system of claim 19, wherein the fluid includes one of NaCl (sodium chloride), CaCl₂ (calcium chloride), MgCl₃ (magnesium chloride), KCl (Potassium chloride), Na₂SO₃ (sodium sulfate), CaSO₄ (calcium sulfate), MgSO₄ (magnesium sulfate), Na₂HPO₄ (sodium hydrogen phosphate), Mg₃(PO₄)₂ (magnesium phosphate tribasic), NaHCO₃ (sodium bicarbonate), CaCO₃ (calcium carbonate), MgCO₃ (magnesium carbonate) or Ringer'"'"'s solution.

38. The system of claim 19 wherein the fluid delivery device delivers fluid to the first and to the second ablation needles.

39. The system of claim 19 wherein a distance between needles tips of the first and second ablation needles is approximately 1±

0.5 centimeters.

40. The system of claim 19 further including:

a first fluid delivery conduit associated with the first ablation needle;

a second fluid delivery conduit associated with the second ablation needle;

a first fluid delivery device to deliver fluid to the prostate via the first fluid delivery conduit and the first ablation needle; and

a second fluid delivery device to deliver fluid to the prostate via the second fluid delivery conduit and the second ablation needle.

41. The system of claim 19 further including first and second annular rings, each of the annular rings corresponding to and circumferentially disposed about one of the first and second bipolar ablation needles.

42. A transurethral ablation system, comprising:

means for creating a virtual electrode at a target tissue site within the prostate of a male patient; and

means for delivering ablation energy between a first needle electrode and a second needle electrode and the electrically conductive fluid.

43. The system of claim 42 wherein the means for creating a virtual electrode comprises means for delivering a conductive fluid to the target tissue site.

44. The system of claim 43 wherein the means for delivering a conductive fluid comprises fluid delivery ports located in at least one of the first or second needle electrodes.

45. The system of claim 44 wherein the means for delivering a conductive fluid further comprises at least one fluid delivery device.