Plasticized bone and soft tissue grafts and methods of making and using same
First Claim
1. A plasticized bone graft, comprising:
- a cleaned bone graft comprising one or more plasticizers.
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Accused Products
Abstract
The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.
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Citations
43 Claims
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1. A plasticized bone graft, comprising:
- a cleaned bone graft comprising one or more plasticizers.
- View Dependent Claims (4, 5, 6, 7)
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2. A plasticized bone graft suitable for transplantation into a human, comprising:
- a bone graft having an internal matrix essentially free from bone marrow elements; and
one or more plasticizers contained in said internal matrix.
- a bone graft having an internal matrix essentially free from bone marrow elements; and
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3. A plasticized bone graft, comprising:
- a cleaned bone graft; and
one or more plasticizers, wherein said cleaned bone graft is impregnated with said one or more plasticizers.
- a cleaned bone graft; and
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8. A method for producing a plasticized bone graft suitable for transplantation into a human, comprising:
- impregnating a cleaned bone graft with one or more plasticizers to produce a plasticized bone graft.
- View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. A plasticized soft tissue graft suitable for transplantation into a human, comprising:
- a cleaned soft tissue graft having an internal matrix; and
one or more plasticizers contained in said internal matrix. - View Dependent Claims (20, 21, 22, 23)
- a cleaned soft tissue graft having an internal matrix; and
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18. A plasticized soft tissue graft, comprising:
- a cleaned, soft tissue graft; and
one or more plasticizers, wherein said cleaned soft tissue graft is impregnated with said one or more plasticizers.
- a cleaned, soft tissue graft; and
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19. A plasticized soft tissue graft, comprising:
- a cleaned, soft tissue graft comprising one or more plasticizers.
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24. A method for producing a plasticized soft tissue graft suitable for transplantation into a human, comprising:
- impregnating a cleaned, soft tissue graft with one or more plasticizers to produce a plasticized soft tissue graft.
- View Dependent Claims (25, 26, 27, 28, 29, 30, 31)
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32. A plasticized bone graft, comprising:
- a cleaned, non-demineralized bone graft comprising one or more plasticizers.
- View Dependent Claims (33)
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34. A plasticized load-bearing, bone graft, comprising:
- a cleaned, load-bearing bone graft comprising one or more plasticizers.
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35. A plasticized load-bearing soft tissue graft, comprising:
- a cleaned, load-bearing soft tissue graft comprising one or more plasticizers.
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36. A plasticized bone graft, comprising:
- a non load-bearing bone graft comprising one or more plasticizers.
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37. A plasticized bone graft, comprising:
- a non-load-bearing bone graft; and
one or more plasticizers, wherein said bone graft is impregnated with said one or more plasticizers.
- a non-load-bearing bone graft; and
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38. A method for producing a plasticized bone graft suitable for transplantation into a human, comprising:
- impregnating a non load-bearing bone graft with one or more plasticizers to produce a plasticized bone graft.
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39. A plasticized soft tissue graft suitable for transplantation into a human, comprising:
- a soft tissue graft having an internal matrix; and
one or more plasticizers contained in said internal matrix. - View Dependent Claims (42, 43)
- a soft tissue graft having an internal matrix; and
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40. A plasticized soft tissue graft, comprising:
- a cleaned soft tissue graft; and
one or more plasticizers, wherein said cleaned soft tissue graft is impregnated with said one or more plasticizers.
- a cleaned soft tissue graft; and
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41. A plasticized soft tissue graft, comprising:
- a soft tissue graft comprising one or more plasticizers.
Specification