Devices and methods for use in assessing a flow condition of a fluid
First Claim
1. A method of assessing a flow condition of a fluid, comprising:
- providing a fluid sufficient to support an electrochemical reaction at a working electrode of an electrochemical cell, the fluid comprising a component sufficient to affect the electrochemical reaction such that the electrochemical reaction is mass-transport limited;
providing at least one electrochemical cell comprising the working electrode and at least one other electrode in communication with the fluid; and
obtaining an indicator of a rate of the electrochemical reaction.
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Accused Products
Abstract
A device for use in assessing a flow condition of a fluid, or a fluid in a flow path, is provided. The device comprises at least one electrochemical cell, comprising a working electrode and at least one other electrode, sufficient for communication with the fluid, or sufficient for communication with a flow path, such that when sufficient fluid is in the flow path, the cell is in communication with the fluid. The fluid comprises a component sufficient to affect a mass-transport limited electrochemical reaction at the working electrode. The device also comprises at least one microcontroller operably connected to the at least one electrochemical cell for providing a potential or a current to the working electrode and for assessing the electrochemical reaction. A method of assessing a flow condition of a fluid, or a fluid in a flow path, is also provided. The device and the method of the present invention may be used in connection with the delivery of a fluid-borne or fluidized drug or medicament to a subject.
108 Citations
90 Claims
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1. A method of assessing a flow condition of a fluid, comprising:
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providing a fluid sufficient to support an electrochemical reaction at a working electrode of an electrochemical cell, the fluid comprising a component sufficient to affect the electrochemical reaction such that the electrochemical reaction is mass-transport limited;
providing at least one electrochemical cell comprising the working electrode and at least one other electrode in communication with the fluid; and
obtaining an indicator of a rate of the electrochemical reaction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A device for use in assessing a flow condition of a fluid sufficient to support an electrochemical reaction, comprising:
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at least one electrochemical cell comprising a working electrode and at least one other electrode, the electrochemical cell sufficient for communication with a path via which the fluid flows, such that when sufficient fluid is in the path, the electrochemical cell is in communication with the fluid;
at least one microcontroller operably connected to the at least one electrochemical cell, the at least one device sufficient to provide a current or a potential to the working electrode sufficient for the electrochemical reaction to take place at the working electrode, the at least one microcontroller sufficient to receive information concerning a mass-transport limiting affect of a component of the fluid on the electrochemical reaction. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90)
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Specification