Cosmetic or dermatological preparation comprising a nutrient medium phase

• US 20050249691A1
• Filed: 10/19/2004
• Published: 11/10/2005
• Est. Priority Date: 05/24/2003
• Status: Abandoned Application

• Current Assignee: La Prairie Group AG (maxingvest GmbH & Co. KGaA)
• Original Assignee: Beiersdorf AG (maxingvest GmbH & Co. KGaA)
• Inventors: Monks, Monika, Ibanez, Sybille, Gohla, Sven, Evangelisti, Carmen
• Application Number:
  US10/967,232
• Publication Number:
  US 20050249691A1
• Time in Patent Office: Days
• US Class Current: 424/70.130
• CPC Class Codes: A61F 2013/00748 with hydrocolloids or superabsorbers
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/20 Halogens; Compounds thereof
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/67 Vitamins
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

A cosmetic or dermatological preparation that comprises collagen and/or a derivative thereof, chitosan and/or a derivative thereof, having a degree of acetylation of up to 50%, and glycosaminoglycan and a derivative thereof.

Claims

1-26. -26. (canceled)

27. A cosmetic or dermatological preparation comprising

(a) at least one of collagen and a derivative thereof;

(b) at least one of chitosan and a derivative thereof, having a degree of acetylation of up to 50%; and

(c) at least one of a glycosaminoglycan and a derivative thereof.

28. The preparation of claim 27, wherein at least one of components (a) and (b) is of marine origin.

29. The preparation of claim 27, wherein at least one of components (a) and (b) is of synthetic origin.

30. The preparation of claim 27, wherein the collagen comprises one or more collagens of type 1, type 3, type 4 and type 5.

31. The preparation of claim 27, wherein the chitosan comprises chitosan obtained from at least one of crustaceans and insects.

32. The preparation of claim 27, wherein the chitosan comprises chitosan having a molecular weight of from 80,000 g/mol to 15,000,000 g/mol.

33. The preparation of claim 27, wherein the glycosaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.

34. The preparation of claim 27, wherein the preparation comprises components (a) to (c) in a concentration of from 0.00001% to 99% by weight, based on a total weight of the preparation.

35. The preparation of claim 34, wherein the preparation comprises from 0.0005% to 50% by weight of components (a) to (c).

36. The preparation of claim 35, wherein the preparation comprises from 0.0015% to 30% by weight of components (a) to (c).

37. The preparation of claim 27, wherein the preparation further comprises at least one substance selected from L-cystine, L-glutamine, hypoxanthine, L-glutamic acid, thymidine, lipoic acid, linoleic acid, L-isoleucine, putrescine 2HCl, NaCl, choline chloride, KCl, putrescine, sodium acetate, vitamin B₁₂, Na₂HPO₄, biotin, calcium pantothenate, CaCl₂, nicotinamide, glucose, pyridoxine HCl, sodium pyruvate, thiamine HCl, NaHCO₃, adenine, phenol red, myo-inositol, HEPES, L-alanine, folic acid, L-arginine HCl, riboflavin, L-asparagine, L-aspartic acid, L-cysteine HCl, FeSO₄, MnSO₄, (NH₄)₆Mo₇O₂₄, glycine, NiCl₂, L-histidine HCl, H₂SeO₃, Na₂SiO₃, SnCl₂, L-lysine HCl, NH₄VO₃, L-proline, L-threonine, L-tryptophan, L-tyrosine, L-valine, insulin human, ZnSO₄, CoCl₂, CuSO₄, Na₂SeO₃, AlCl₃, CrK(SO₄)₂, NiCl₃, MnCl₂, EDTA.Na₂, polysorbate 80, L-leucine, L-methionine, NaH₂PO₄, L-phenylalanine, MgCl₂, L-serine, Fe(NO₃)₃, L-tyrosine, α

-biotin, D-Ca pantothenate, and pyridoxal HCl.

38. The preparation of claim 27, wherein the preparation comprises components (a) to (c) as at least one of a nanosponge matrix and a microsponge matrix which is reconstituted in cell culture media.

39. The preparation of claim 27, wherein a ratio of collagen and chitosan is 60-90% to 40-10%.

40. The preparation of claim 39, wherein the ratio is 75-85% to 25-15%.

41. The preparation of claim 38, wherein the cell culture media is selected from physiological saline solution, nutrient medium and complete medium for culturing healthy, primary body cells.

42. The preparation of claim 41, wherein the media are derived from culture media for primary fibroblasts and keratinocytes.

43. The preparation of claim 41, wherein the complete media are supplemented with serum substitutes.

44. The preparation of claim 27, wherein the preparation further comprises one or more skin culture media selected from one or more of DMEM/HAM'"'"'s F-12 (1:

1) and MCDB 153.

45. The preparation of claim 27, wherein the preparation further comprises a citrate buffer.

46. The preparation of claim 27, wherein the preparation is based on one of an aqueous gel, an O/W emulsion, a WIOIW emulsion, a W/O emulsion, a microemulsion and a cosmetic stick.

47. The preparation of claim 27, wherein the preparation further comprises at least one of Q10, AGR, Zn orotate, carnitine, creatine and taurine.

48. An article which comprises the preparation of claim 27, wherein the article is selected from a wound covering, a skin covering, a patch, a pad, a tissue and a bandage.

49. The preparation of claim 27, wherein the preparation is present as a constituent of a polyurethane matrix.

50. The preparation of claim 27, wherein the preparation is present as one of an aqueous surfactant preparation, an emulsion, an ointment, a cream, a gel, a dusting powder, a mask, a matrix bandage, a gel bandage, a foam and an aerosol preparation.

51. A skin care method, wherein the method comprises applying to skin the preparation of claim 27.

52. A skin treatment method, wherein the method comprises applying to injured or diseased skin the preparation of claim 27.

53. A method of wound management or wound healing, wherein the method comprises applying to a wound the preparation of claim 27.

54. The method of claim 53, wherein the preparation is comprised in a wound covering.

55. The method of claim 54, wherein the wound covering comprises a polyurethane.

56. A method of generating a complete partial skin, wherein the method comprises applying the preparation of claim 27 to a surface of a body from which skin has been removed.

57. A method of preventing or reducing scar tissue, wherein the method comprises applying to a wound the preparation of claim 27.

58. A process for preparing a cosmetic or dermatological preparation comprising at least one of collagen and a derivative thereof;

at least one of chitosan and a derivative thereof, having a degree of acetylation of up to 50%; and

at least one of a glycosaminoglycan and a derivative thereof;

wherein the process comprises

(a) providing a solution comprising water and at least one of collagen and a derivative thereof;

(b) adding at least one of chitosan and a derivative thereof, having a degree of acetylation of up to 50%, to the solution of (a) to form a mixture; and

(c) adding at least one of a glycosaminoglycan and a derivative thereof to the mixture of (b) to form a further mixture.

59. The process of claim 58, wherein the solution of (a) further comprises a cell culture medium.

60. The process of claim 58, wherein the glycosaminoglycan comprises at least one of chondroitin 4-sulfate and chondroitin 6-sulfate.

61. The process of claim 58, wherein the process further comprises (d) lyophilizing the mixture of (c) to provide an aerogel.

62. The process of claim 61, wherein the process further comprises converting the aerogel of (d) into a hydrogel by introducing the aerogel into one of an aqueous phase, an active ingredient phase and a culture media phase of the cosmetic or dermatological preparation.

63. The process of claim 61, wherein the process further comprises processing the aerogel of (d) into a polyurethane matrix.