Compositions and methods for the inhibition of bone growth and resorption
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Abstract
A composition, or article for inhibition of bone growth and resorption comprises an anti-inflammatory agent(s), optionally other agents and carriers, monomer(s), oligomer(s), polymer(s), salt(s), mixtures(s), dispersion(s) and/or blend(s) thereof, which composition, device, or implant upon polymer erosion releases a bone growth and/or bone resorption retarding, reducing or inhibiting amount of the agent(s). The monomers, oligomers and polymers, releasing active or activatable agent(s), have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The monomers, oligomers and polymers may be prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The composition, device, implant or dressing of this patent are suitable for retarding, reducing or inhibiting bone growth or bone resorption, comprising administering or applying to a subject'"'"'s pre-selected site a bone growth or resorption reducing amount of the agent(s).
104 Citations
95 Claims
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1. -75. (canceled)
- 76. A method of inhibiting bone growth or bone resorption comprising administering to a site where inhibition of bone growth or resorption is desired an effective amount of at least one anti-inflammatory agent having at least two reactive functional groups, which agent is incorporated into a biodegradable monomer or into the backbone of a biodegradable oligomer or polymer.
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84. The method of 79, wherein the bone growth or bone resorption is inhibited by at least 50% as compared to the bone growth or bone resorption in the absence of the anti-inflammatory agent.
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