Monoclonal antibodies with enhanced ADCC function
First Claim
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1. A monoclonal antibody having on its Fcγ
- glycosylation site (Asn
297) short chain bi-antennary glycan structures, with a low degree of sialylation and nonintercalated mannose or nonintercalated GlcNAc at a terminal point of attachment, wherein said glycan structures are selected from the group consisting of and wherein said antibody has a fucose content less than 65%.
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Abstract
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP)
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18 Claims
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1. A monoclonal antibody having on its Fcγ
- glycosylation site (Asn
297) short chain bi-antennary glycan structures, with a low degree of sialylation and nonintercalated mannose or nonintercalated GlcNAc at a terminal point of attachment, wherein said glycan structures are selected from the group consisting ofand wherein said antibody has a fucose content less than 65%. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- glycosylation site (Asn
Specification