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Monoclonal antibodies with enhanced ADCC function

  • US 20050249722A1
  • Filed: 01/24/2005
  • Published: 11/10/2005
  • Est. Priority Date: 04/12/2000
  • Status: Active Grant
First Claim
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1. A monoclonal antibody having on its Fcγ

  • glycosylation site (Asn

         297) short chain bi-antennary glycan structures, with a low degree of sialylation and nonintercalated mannose or nonintercalated GlcNAc at a terminal point of attachment, wherein said glycan structures are selected from the group consisting of and wherein said antibody has a fucose content less than 65%.

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