Methods of implating mesenchymal stem cells for tissue repair and formation
First Claim
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1. A method of obtaining an isolated, non-culture expanded mesenchymal stem cell, comprising the following steps:
- Contacting a human cell population with an antibody that binds to a surface molecule expressed on a mesenchymal stem cell within said human cell population, so as to form a cell-antibody-complex;
Recovering said mesenchymal stem cell;
Maintaining said recovered mesenchymal stem cell under conditions preventing significant cellular expansion;
thereby obtaining a non-culture expanded mesenchymal stem cell.
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Abstract
The invention relates to methods of isolating and implanting mesenchymal stem cells for tissue repair or formation, without prior culture expansion of the mesenchymal stem cells. In particular, the invention relates to methods of isolating mesenchymal stem cells from bone marrow, for repairing or inducing formation of bone, without prior culture expansion of the mesenchymal stem cells. The invention further relates to an isolated, non-culurally expanded human adult mesenchymal stem cell population.
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Citations
24 Claims
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1. A method of obtaining an isolated, non-culture expanded mesenchymal stem cell, comprising the following steps:
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Contacting a human cell population with an antibody that binds to a surface molecule expressed on a mesenchymal stem cell within said human cell population, so as to form a cell-antibody-complex;
Recovering said mesenchymal stem cell;
Maintaining said recovered mesenchymal stem cell under conditions preventing significant cellular expansion;
thereby obtaining a non-culture expanded mesenchymal stem cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15)
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14. Use of an isolated, non-culture expanded mesenchymal stem cell in the preparation of a medicament for stimulating or enhancing tissue formation in a subject, wherein the non-culture expanded mesenchymal stem cell is obtained via the method of caim 1.
- 16. Isolated, non-culture expanded human adult mesenchymal stem cells.
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