Antimicrobial articles

• US 20050249791A1
• Filed: 05/07/2004
• Published: 11/10/2005
• Est. Priority Date: 05/07/2004
• Status: Abandoned Application

• Current Assignee: 3M Innovative Properties Company (3M Company)
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Gryska, Stefan H., Hobbs, Terry R., Lucast, Donald H., Sebastian, John M.
• Application Number:
  US10/841,858
• Publication Number:
  US 20050249791A1
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A61F 13/0203 with fluid retention members
• CPC Class Codes: A61F 2013/8414 with anti-microbic
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 15/48 Surfactants
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/608 having two or more layers

Abstract

An antimicrobial article is disclosed comprising a layer of a thermoplastic polymer, and an adhesive layer having a antimicrobial agent dispersed therein. The antimicrobial article is useful, for example, surgical tapes, surgical drapes and wound dressings, and as disposable surfaces for food preparation and handling.

Claims

1. An antimicrobial article comprising:

a thermoplastic polymer layer having a first surface and a second surface having an adhesive layer bonded to said second surface, said adhesive layer comprising an antimicrobial agent that migrates to said first surface of said polymeric layer.

2. The antimicrobial article of claim 1 wherein said polymeric layer comprises films, porous membranes, microporous membranes, and fibrous polymer layers.

3. The antimicrobial article of claim 1 wherein said antimicrobial agent is selected from iodine and iodophors, chlorhexidine salts;

parachlorometaxylenol;

triclosan;

hexachlorophene;

fatty acid monoesters of glycerol and propylene glycols;

phenols;

polyquaternary amines;

quaternary silanes;

hydrogen peroxide;

silver and silver salts, silver oxide and silver sulfadiazine.

4. The antimicrobial article of claim 3 wherein said fatty acid monoesters are selected from glycerol monolaurate, glycerol monocaprylate, glycerol monocaprate, propylene glycol monolaurate, propylene glycol monocaprylate, propylene glycol monocaproate

8. The antimicrobial article of claim 1 wherein said polymeric layer is selected from polyesters, polyurethanes, polyamides and polyolefins.

9. The antimicrobial article of claim 1 wherein said polymeric layer is selected from homo- and copolymers of aliphatic mono-alpha olefins.

10. The antimicrobial article of claim 1 wherein said polymeric layer is selected from homo-, co- and terpolymers of ethylene and propylene.

11. The antimicrobial article of claim 1, wherein said adhesive layer is a pressure sensitive adhesive layer.

12. The antimicrobial article of claim 1 further comprising a release liner.

13. The antimicrobial article of claim 1, wherein said thermoplastic polymer layer is patterned.

14. The antimicrobial article of claim 1 wherein said adhesive layer is patterned.

15. The article of claim 1 wherein said thermoplastic polymer layer is a nonductile polymer layer.

17. The article of claim 1, wherein said thermoplastic polymer layer has a diffusion constant of greater than 10×

10<sup>−

10</sup> cm²/s at 25°

C.

18. The article of claim 1, wherein said thermoplastic polymer layer has a diffusion constant of greater than 100×

10 cm²/s at 25°

C.

19. The article of claim 1, wherein said adhesive layer further comprises a surfactant dispersed in said adhesive layer.

20. The article of claim 19, wherein said surfactant is selected form nonionic, amphoteric and anionic surfactants.

21. The article of claim 19 wherein said surfactant is present in amount of at least 0.05 wt. %, relative to the weight of the adhesive layer.

22. A multilayer article comprising a plurality of antimicrobial articles of claim 1.

23. The multilayer article of claim 22 in the form of a stack.

24. The article of claim 1, wherein said antimicrobial agent dispersed in said adhesive comprises an delivery system to facilitate the migration of such antimicrobial agents from the adhesive layer into adjoining thermoplastic polymer layer, and provide for replenishment of the antimicrobial agent.

25. The article of claim 1, wherein said thermoplastic polymer layer has a T_g of below about 0°

C.

38. A wound dressing comprising the antimicrobial article of claim 1.

39. The wound dressing of claim 38 comprising a thermoplastic polymer facing layer, an adhesive layer on at least a portion of said facing layer, a backing layer, and a gel layer disposed between said facing and backing layers, said adhesive layer containing an antimicrobial agent.

40. A food preparation surface comprising the antimicrobial article of claim 1.

5. The antimicrobial article of claim I wherein said adhesive layer provides a reservoir for gradual release of said antimicrobial agent.

6. The antimicrobial article of claim 5 wherein said adhesive layer comprises at least 0.25 wt. % of said antimicrobial agent.

7. The antimicrobial article of claim 6 wherein said adhesive layer comprises 0.25 to 40 wt. % of said antimicrobial agent.

16. The article of claims I wherein said adhesive layer is a repositionable adhesive layer.

26. A method for providing an antimicrobial article comprising a thermoplastic polymer layer and an adhesive layer, comprising the steps of:

(a) dispersing into an adhesive layer at least one antimicrobial agent; and

(b) adhering the adhesive layer to a thermoplastic polymer layer, wherein the adhesive layer provides a antimicrobial agent reservoir for the polymer layer.

27. The method of claim 26 wherein said thermoplastic polymer layer comprises a film, a membrane, or a fibrous polymer layer.

28. The method of claim 26 wherein said antimicrobial agent is present in an amount sufficient to render said thermoplastic polymer layer antimicrobial.

29. The method of claim 26 wherein said adhesive layer comprises at least 0.25 wt. % of said antimicrobial agent.

30. The method of claim 26, wherein said thermoplastic polymer layer has a permeability coefficient of greater than 10×

10<sup>−

10</sup> cm²/s at 25°

C.

31. The method of claim 26 wherein said adhesive layer is coated onto said thermoplastic polymer layer.

32. The method of claim 26 wherein said thermoplastic polymer layer and said adhesive layer are coextruded.

33. The method of claim 26 wherein said polymeric layer is selected from polyesters, polyurethanes, polyamides and polyolefins.

34. The method of claim 26 wherein said polymeric layer is selected from homo-, co-and terpolymers of aliphatic mono- alpha olefins.

35. The method of claim 26 wherein said polymeric layer is selected from homo-, co-and terpolymers of ethylene and propylene.

36. The method of claim 26, wherein said adhesive layer is a pressure sensitive adhesive layer.

37. The method of claim 26, wherein said adhesive layer is a repositionable adhesive layer.