Inhibitors of histone deacetylase
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Abstract
Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.
59 Citations
32 Claims
- 1. A compound of formula I:
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27. A compound selected from the group consisting of:
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1-(2-naphthylsulfonyl)-4-(5-hydroxyaminocarbonylthiazol-2-yl) piperazine;
1-(2-naphthylsulfonyl)-4-(5-hydroxyaminocarbonylthiazol-2-yl)-1,4-diazepane;
1-(2-naphthylsulfonyl)-4-(4-hydroxyaminocarbonylthiazol-2-yl) piperazine;
1-(2-naphthylsulfonyl)-4-[(5-(2-hydroxyaminocarbonylethen-1(Z)-yl-thiazol-2yl)piperazine;
4-(2-naphthylsulfonylamino)-1-[(5-(2-hydroxyaminocarbonyl-thiazol-2-yl)-piperadine;
2-[4-(3,4-dimethoxy-benzene sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-trifluoromethoxy-benzene sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4 toluene-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-nitro-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-acetyl-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(thiophene-2-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(biphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(5-dimethylamino-naphthalene-1-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-fluoro-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-(4-methyl-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxyamide;
2-(4-Benzyl-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxyamide;
2-(4-(2-hydroxyethyl)-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxyamide;
2-(4-(2-aminoethyl)-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxyamide;
2-(4-phenylethyl-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxyamide;
2-(4-acetyl-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxamide;
2-(4-benzoyl-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxamide;
2-(4-phenylacetyl-piperazin-1-yl)-thiazole-5-carboxylic acid hydroxamide;
N-(2-naphthylsulfonyl)-N-′
-{2-[5-(N-hydroxycarboxamido)]thiazolyl}-piperazine;
2-[4-(naphtha-2-yl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-trifluoromethoxy-benzene sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-toluene-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(biphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-trifluoromethyl-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,4-dimethoxy-benzene sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(5-dimethylamino-naphthalene-1-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-acetyl-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-nitro-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-fluoro-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-pyrolidinylbenzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(thiophene-2-benzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(N-methyl-2,3-dihydrobenzisoxazinylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-isopropylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(trans-2-phenylethanelsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-chlorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-chlorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,4-dichlorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(N,N-dimethylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-methylsufonylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(pyridine-3-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-methylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-methylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-[(dimethylamino)methyl]-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-n-propylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,5-dimethylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-t-butylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(benzylsulfonyl)piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4′
-N,N-dimethylcarboxamido-1,1′
-biphenylsulfonyl)piperazin-1-yl]-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4′
-methylsulfonylamino-1,1′
-biphenylsulfonyl)piperazin-1-yl]-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(4′
-((dimethylamino)methyl)-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,5-dimethylisoxazolesulfonyl)piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-({4-morpholino}-3-pyridylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3′
-(dimethylamino)-1,1′
-biphenylsulfonyl)piperazin-1-yl]-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-(pyrrolidin-1-ylmethyl 1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-dimethylaminophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,4-dimethylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4′
-(morpholin-4-ylcarbonyl) 1,1′
-biphenylsulfonyl)piperazin-1-yl]-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{4-[(2-((dimethylamino)-methyl)thien-3-yl]phenylsulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(4′
-fluoro-1,1′
-biphenyl-4-yl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-chloro-2-methylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-chloro-4-methylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-methoxyphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[4-(pyridin-4-yl)phenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-fluorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-fluorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-methyl-5-fluorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-trifluoromethylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-chloro-1,1′
-biphenyl-4-yl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(2′
-chloro-1,1′
-biphenyl-4-yl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[4-(2-furyl)phenyl]sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,4-difluorophenylsulfonyl)piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-fluoro-2-methylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-fluoro-4-methylphenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-methyl-6-chlorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2,5-dimethyl-4-chlorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2,1,3-benzothiadiazole-5-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-benzothiphenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2,3-dihydrobenzofuransulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,4-benzodioxansulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-biphenylsulfonyl)piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-phenoxypyridine-5-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(2-{2-methylthiopyrimidine-4-yl}-5-thiophenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-(4-[4-{(2-(pyrrolidin-1-ylmethyl)-thien-3-yl)phenylsulfonyl}]-piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{4-[(5-(pyrrolidin-1-ylmethyl)-thien-2-yl]phenylsulfonyl}-piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-((4-methylpiperazin-1-yl)methyl)-1,1′
-biphenylsulfonyl]-piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[(2-(dimethylamino)ethyl)(methyl)amino]methyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3,5-difluorophenylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{4-[(3-(pyrrolidin-1-ylmethyl)-thien-2-yl]phenylsulfonyl}-piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-[isopropyl(methyl)amino]methyl]-1,1′
-biphenylsulfonyl]-piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-[ethyl(methyl)amino]methyl]-1,1′
-biphenylsulfonyl]-piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-fluoro-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[4-(1,3-benzodioxol-5-yl)phenyl]sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(n-butylsulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(chlorophenylsulfonyl)piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(5-bromothien-2-yl)sulfonyl]piperazin-1-yl}-N-hydroxy-1,3-thiazole-5-carboxamide;
2-{4-[(4′
-chloro-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(4′
-methoxy-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(4′
-(2,2-dimethylpropyl)-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(4-thien-2-ylphenyl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxamide;
2-(4-{[4-(1-(2,2-dimethylprop-oxycarbonyl)-1H-pyrrol-2-yl)phenyl]-sulfonyl}-piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[4-(1H-pyrrol-2-yl)phenyl]sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-(piperidin-1-ylmethyl)-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-(4-methylpiperidin-1-ylmethyl)-1,1′
-biphenylsulfonyl]-piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-(hexahydroazepin-1-ylmethyl)-1,1′
-biphenylsulfonyl]-piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-((diethylamino)methyl)-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(3′
-((methyl(3-propenyl)amino)methyl)phenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{4-[(3-(pyrrolidin-1-ylmethyl)-2-furyl]phenylsulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{5-[3-(pyrrolidin-1-ylmethyl)phenyl]thiophene-2-sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-pyrzaol-1-yl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-{1-methylimidazol-4-yl}-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-methoxyphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-{3-trifluoromethylphenyl}-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-{N,N-dimethylaminomethylphenyl}-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-{N-morpholinomethylphenyl}-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-{N-pyrrolidinylmethylphenyl}-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-phenethylphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-ethylphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-hydroxymethylphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-pyrrolidin-1-ylmethylphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-pyrimid-5-ylphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(4′
-(acetamidophenyl)-phenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-pyridylphenyl-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-{N,N-dimethylaminomethylphenyl}-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-methoxymethylbenzenesulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(4-acetamido-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-[4-(3-cyanophenyl}-4-sulfonyl)-piperazin-1-yl]-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(2-chloro-5-methoxyphenyl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[3-(difluoromethoxy)phenyl]sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(4-methyl-3-nitrophenyl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(2,5-dimethoxyphenyl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(2,5-dimethylphenyl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[2-(pyrrolidin-1-ylmethyl)-4-methylphenyl]sulfonyl}piperazin 1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[3-fluoro-4-(pyrrolidin-1-yl)phenyl]sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[4-(piperidin-1-yl)phenyl]sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{[4-(morpholin-4-yl)phenyl]sulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[(trifluoromethyl)sulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[ethylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[N-acetylamino]methyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{methoxymethyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[4-(2-(pyrrolidin-1-ylmethyl)-thien-4-yl)phenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{4-[3-((dimethylamino)-methyl)-2-furyl]phenylsulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{4-[(4-(pyrrolidin-1-ylmethyl)-2-furyl]phenylsulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-(4-{4-[(3-((dimethylamino)methyl thien-2-yl]phenylsulfonyl}piperazin-1-yl)-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[(2-hydroxyethyl)(methyl)amino]methyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[bis(2-hydroxyethyl)amino]methyl)}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-(3,6-dihydropyridin-1 (2H)-ylmethyl 1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[(butyl)(methyl)amino]methyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-((piperazin-1-yl)methyl 1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[(2-methoxyethyl)(methyl)amino]methyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[bis(3-propenyl))amino]methyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[3′
-{[methylamino]methyl)}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
2-{4-[2′
-{pyrrolidin-1-ylmethyl}-1,1′
-biphenylsulfonyl]piperazin-1-yl}-1,3-thiazole-5-carboxylic acid hydroxyamide;
and tautomers, isomers, prodrugs and pharmaceutically acceptable salts thereof.
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Specification