Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity
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Abstract
The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, W, X, Z, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
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Citations
36 Claims
- 1. A compound of the formula I:
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27. The compound of claim I wherein R3 is hydrogen and phenyl, where the phenyl is unsubstituted or substituted with 1-3 substituents where the substituents are independently selected from:
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(a) halo, (c) hydroxy, (d) C1-3alkyl, (e) —
O—
C1-3alkyl, and(f) —
CO2R9.
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31. A compound which is selected from the group consisting of the title compounds of the Examples, and pharmaceutically acceptable salts and individual diastereomers thereof.
Specification