Methods for treating neuropsychiatric disorders
First Claim
1. A method for treating a neuropsychiatric disorder in a patient, the method comprising administering to a patient suffering from a neuropsychiatric disorder a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of N-methylglycine, a salt of N-methylglycine, an ester of N-methylglycine, alkylated N-methylglycine, and a precursor of N-methylglycine, wherein the pharmaceutical composition is administered at a dose equivalent to 10 mg to 10 g N-methylglycine per day.
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Accused Products
Abstract
The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer'"'"'s Disease, autism, depression, benign forgetfulness, childhood learning disorders, closed head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).
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Citations
21 Claims
- 1. A method for treating a neuropsychiatric disorder in a patient, the method comprising administering to a patient suffering from a neuropsychiatric disorder a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of N-methylglycine, a salt of N-methylglycine, an ester of N-methylglycine, alkylated N-methylglycine, and a precursor of N-methylglycine, wherein the pharmaceutical composition is administered at a dose equivalent to 10 mg to 10 g N-methylglycine per day.
- 12. A method for treating a positive symptom of schizophrenia, the method comprising administering to a patient suffering from a positive symptom of schizophrenia a pharmaceutical composition comprising a therapeutically effective amount of a compound selected from the group consisting of N-methylglycine, a salt of N-methylglycine, an ester of N-methylglycine, alkylated N-methylglycine, and a precursor of N-methylglycine.
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21. A method for treating schizophrenia, the method comprising administering to a patient suffering from schizophrenia a pharmaceutical composition comprising a therapeutically effective amount of N,N,N-trimethylglycine or N,N-dimethylglycine.
Specification