Method and apparatus for assessing autonomic function

• US 20050251051A1
• Filed: 06/04/2004
• Published: 11/10/2005
• Est. Priority Date: 05/10/2004
• Status: Abandoned Application

• Current Assignee: Meddorna LLC
• Original Assignee: MedPond, LLC
• Inventors: Ferris, Mark, Zhirnov, Yevgeniy N., Gribkov, Evgueni N., Pougatchev, Vadim I.
• Application Number:
  US10/861,932
• Publication Number:
  US 20050251051A1
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system

Abstract

The invention analyzes relationships between factors, within a patient population, to identify autonomic dysfunction patterns. Patient test results are then compared with the identified patterns to determine the patient'"'"'s autonomic function. The invention can continually amend the patient population with new test results to create increasingly accurate normative data sets from which a patient'"'"'s autonomic function can be more accurately assessed. The invention may apply this concept in an application service provider model. An embodiment of the invention may use a novel method of identifying ECG R-waves. The method locates R-waves by searching for maximum slope values, in signals, that exceed threshold values. Another embodiment of the invention entails utilizing data from a non-provocative HRV test and a provocative HRV test in an assessment tool to assess a patient'"'"'s autonomic function.

Claims

1. A method for assessing autonomic function comprising the steps of:

obtaining first physiologic data of a patient wherein the first physiologic data is derived from one or more non-provocative studies;

obtaining second physiologic data of the patient wherein the second physiological data is derived from one or more provocative studies; and

utilizing the first and second physiological data in an assessment tool for assessing the patient'"'"'s autonomic function.

2. The method of claim 1 wherein the assessment tool comprises an autonomic ranking.

3. The method of claim 2 wherein the autonomic ranking comprises one or more numbers.

4. The method of claim 1 wherein the assessment tool comprises a discriminant equation that discriminates between a first group of patients with a first state of autonomic function and a second group of patients with a second state of autonomic function.

5. The method of claim 1 wherein the assessment tool comprises a data set of normative values.

6. The method of claim 1 wherein the one or more non-provocative studies comprise the step of recording the first physiologic data from the patient while the patient is breathing normally.

7. The method of claim 6 wherein the one or more non-provocative studies further comprise the step of recording the first physiologic data from the patient while the patient is in a substantially reclined position.

8. The method of claim 7 wherein the one or more non-provocative studies further comprise the step of recording the first physiologic data from the patient for one or more periods of approximately five minutes.

9. The method of claim 1 wherein the one or more provocative studies are selected from the group consisting of:

Orthostatic test, Metronomic test, Valsalva test and combinations thereof.

10. The method of claim 1 wherein the first physiologic data comprises one or more measurements selected from the group consisting of:

RMS-SD, NN, SDNN, TP, LFnorm, HFnorm, LF/HF, VLF, LF, HF and combinations thereof.

11. The method of claim 1 wherein the second physiologic data comprises one or more measurements selected from the group consisting of:

30;

15 Ratio, NNmin Standing, NNmax Standing, Tmax, Trec, E/I Ratio, SD, NNmin SB, NNmax SB, VARmax, VARmean, VR and combinations thereof.

12. The method of claim 1 wherein the first physiologic data comprises ECG data.

13. The method of claim 1 wherein the first physiologic data comprises blood pressure data.

14. The method of claim 1 wherein the patient is non-human.

15. One or more program storage media readable by a machine and containing instructions for performing the method contained in claim 1.

16. A system for assessing autonomic performance comprising:

one or more memory units operable for storing one or more computer products for assessing autonomic performance; and

one or more processors coupled to the one or more memory units, wherein the one or more processors execute the one or more computer products for performing the steps of;

obtaining first physiologic data of a patient wherein the first physiologic data is derived from one or more non-provocative studies;

obtaining second physiologic data of the patient wherein the second physiological data is derived from one or more provocative studies; and

utilizing the first and second physiological data in an assessment tool for assessing the patient'"'"'s autonomic function.

17. The system of claim 16 wherein the assessment tool comprises an autonomic ranking.

18. The system of claim 17 wherein the autonomic ranking comprises one or more numbers.

19. The system of claim 16 wherein the assessment tool comprises a discriminant equation that discriminates between a first group of patients with a first state of autonomic function and a second group of patients with a second state of autonomic function.

20. The system of claim 16 wherein the assessment tool comprises a data set of normative values.

21. The system of claim 16 wherein the one or more non-provocative studies comprise the step of recording the first physiologic data from the patient while the patient is breathing normally.

22. The system of claim 21 wherein the one or more non-provocative studies further comprise the step of recording the first physiologic data from the patient while the patient is in a substantially reclined position.

23. The system of claim 16 wherein the one or more provocative studies are selected from the group consisting of:

Orthostatic test, Metronomic test, Valsalva test and combinations thereof.

24. The system of claim 16 wherein the first physiologic data comprises one or more measurements selected from the group consisting of:

RMS-SD, NN, SDNN, TP, LFnorm, HFnorm, LF/HF, VLF, LF, HF and combinations thereof.

25. The system of claim 16 wherein the second physiologic data comprises one or more measurements selected from the group consisting of:

30;

15 Ratio, NNmin Standing, NNmax Standing, Tmax, Trec, E/I Ratio, SD, NNmin SB, NNmax SB, VARmax, VARmean;

VR and combinations thereof.

26. The system of claim 16 wherein the first physiologic data comprises ECG data.

27. The system of claim 16 wherein the first physiologic data comprises blood pressure data.

47. The system of claim 16 wherein the patient is non-human.

28. A method for assessing autonomic function comprising:

obtaining first physiologic data of a patient wherein the first physiologic data is derived from one or more non-provocative studies;

deriving first HRV data from the first physiologic data;

obtaining second physiologic data of the patient wherein the second physiological data is derived from one or more provocative studies;

deriving second HRV data from the second physiologic data; and

inputting the first and second HRV data into a discriminant equation to provide an autonomic ranking that is indicative of an autonomic function of the patient;

wherein the discriminant equation discriminates between a first group of patients with a first state of autonomic function and a second group of patients with a second state of autonomic function.

29. The method of claim 28 wherein the one or more non-provocative studies comprise the step of recording the first physiologic data from the patient while the patient is breathing normally.

30. The method of claim 29 wherein the one or more non-provocative studies further comprise the step of recording the first physiologic data from the patient while the patient is in a substantially reclined position.

31. The method of claim 28 wherein the one or more provocative studies are selected from the group consisting of:

Orthostatic test, Metronomic test, Valsalva test and combinations thereof.

32. The method of claim 28 wherein the first HRV data comprises one or more measurements selected from the group consisting of:

RMS-SD, NN, SDNN, TP, LFnorm, HFnorm, LF/HF, VLF, LF, HF and combinations thereof.

33. The method of claim 28 wherein the second HRV data comprises one or more measurements selected from the group consisting of:

30;

15 Ratio, NNmin Standing, NNmax Standing, Tmax, Trec, E/I Ratio, SD, NNmin SB, NNmax SB, VARmax, VARmean, VR and combinations thereof.

34. The method of claim 28 wherein the patient is non-human.

35. One or more program storage media readable by a machine and containing instructions for performing the method contained in claim 28.

36. A method for assessing autonomic function comprising:

obtaining first physiologic data of a patient wherein the first physiologic data is derived from one or more non-provocative studies;

obtaining second physiologic data of the patient wherein the second physiological data is derived from one or more provocative studies;

inputting the first and second physiologic data into a discriminant equation which discriminates between a first group of patients with a first state of autonomic function and a second group of patients with a second state of autonomic function; and

generating an autonomic ranking that is indicative of an autonomic function of the patient from the first and second physiologic data input into the discriminant equation.

37. The method of claim 36 wherein the one or more non-provocative studies comprise the step of recording the first physiologic data from the patient while the patient is breathing normally.

38. The method of claim 37 wherein the one or more non-provocative studies further comprise the step of recording the first physiologic data from the patient while the patient is in a substantially reclined position.

39. The method of claim 36 wherein the one or more provocative studies are selected from the group consisting of:

Orthostatic test, Metronomic test, Valsalva test and combinations thereof.

40. One or more program storage media readable by a machine and containing instructions for performing the method contained in claim 36.

41. A method for assessing autonomic function comprising the steps of:

obtaining physiologic data of a patient wherein the physiologic data is selected from the group consisting of;

first data, second data, combinations thereof and derivations thereof;

wherein the first data is derived from one or more non-provocative studies; and

wherein the second data is derived from one or more provocative studies; and

utilizing the physiological data in an assessment tool for assessing the patient'"'"'s autonomic function.

42. The method of claim 41 wherein the assessment tool comprises an autonomic ranking.

43. The method of claim 41 wherein the assessment tool comprises a discriminant equation that discriminates between a first group of patients with a first state of autonomic function and a second group of patients with a second state of autonomic function.

44. The method of claim 41 wherein the one or more non-provocative studies comprise the step of recording the first physiologic data from the patient while the patient is breathing normally.

45. The method of claim 41 wherein the one or more provocative studies are selected from the group consisting of:

Orthostatic test, Metronomic test, Valsalva test and combinations thereof.

46. One or more program storage media readable by a machine and containing instructions for performing the method contained in claim 41.