Biointerface with macro-and micro-architecture
First Claim
1. A biointerface membrane comprising:
- a macro-architecture defining a plurality of interconnected cavities that are greater than or equal to about 20 microns in a longest dimension; and
a micro-architecture located within at least some of the cavities of the macro-architecture, wherein the micro-architecture comprises elongated strands of material that are less than or equal to about 20 microns in a shortest dimension.
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Abstract
Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
481 Citations
20 Claims
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1. A biointerface membrane comprising:
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a macro-architecture defining a plurality of interconnected cavities that are greater than or equal to about 20 microns in a longest dimension; and
a micro-architecture located within at least some of the cavities of the macro-architecture, wherein the micro-architecture comprises elongated strands of material that are less than or equal to about 20 microns in a shortest dimension. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A biointerface membrane comprising:
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a macro-architecture defining a plurality of interconnected cavities that are greater than or equal to about 20 microns in a longest dimension; and
a micro-architecture located within at least some of the cavities of the macro-architecture, wherein the micro-architecture has a nominal cavity size of less than or equal to about 20 microns. - View Dependent Claims (16)
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- 17. A biointerface membrane comprising macro-architectures and micro-architectures, wherein the macro-architectures and the micro-architectures are co-continuous and interconnected, wherein the macro-architectures and the micro-architectures, when disposed on an implantable device, are adapted to promote vascularization within the biointerface membrane and to interfere with barrier cell layer formation, and wherein the biointerface membrane is configured to facilitate long-term analyte transport in vivo.
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19. A biointerface membrane comprising:
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a first architecture comprising cavities configured to facilitate ingrowth of invasive cells and vascular tissue into the biointerface membrane; and
a second architecture comprising cavities configured to facilitate ingrowth of invasive cells into the biointerface membrane while not permitting ingrowth of vascular tissue. - View Dependent Claims (20)
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Specification