Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter

• US 20050251116A1
• Filed: 05/03/2005
• Published: 11/10/2005
• Est. Priority Date: 05/05/2004
• Status: Abandoned Application

• Current Assignee: Vessix Vascular, Inc. (Boston Scientific Corporation)
• Original Assignee: A Delaware Limited Liability Company, Minnow Medical LLC
• Inventors: Stone, Corbett W., Steinke, Tom A., Michel, Raphael M.
• Application Number:
  US11/122,263
• Publication Number:
  US 20050251116A1
• Time in Patent Office: Days
• US Class Current: 606/8
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 2018/00982 combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
• CPC Class Codes: A61B 2018/2272 with reflective or refractive surfaces for deflecting the beam A61B2018/2261, A61B2018/2266 take precedence
• CPC Class Codes: A61B 2090/373 using light, e.g. by using optical scanners
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

Devices, systems, and methods for treating atherosclerotic lesions and other disease states, particularly for treatment of vulnerable plaques, can incorporate optical coherence tomography or other imaging techniques which allow a structure and location of an eccentric plaque to be characterized. Remodeling and/or ablative laser energy can then be selectively and automatically directed to the appropriate plaque structures, often without imposing mechanical trauma to the entire circumference of the lumen wall.

Claims

1. A catheter system for removal of atherosclerotic material from a blood vessel of a patient, the system comprising:

an elongate flexible catheter having a proximal end and a distal end with an axis therebetween, the catheter having at least one window for transmission of laser energy near the distal end;

at least one optical conduit extending between the proximal end of the catheter and the at least one window;

an optical coherence tomographer coupled to the at least one optical conduit, the tomographer generating image signals from imaging light from a plaque, the imaging light transmitted through the at least one window and proximally along the optical conduit; and

an ablation laser coupled to the tomographer, the ablation laser transmitting plaque-ablating laser energy to the at least one optical conduit in response to the imaging signals.

2. A catheter system for remodeling of atherosclerotic material within a blood vessel of a patient, the system comprising:

an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having at least one window for transmission of laser energy near the distal end;

at least one optical conduit extending between the proximal end of the catheter and the at least one window;

an optical coherence tomographer coupled to the at least one optical conduit, the tomographer generating image signals from imaging light from a plaque, the imaging light transmitted through the at least one window; and

a remodeling laser coupled to the tomographer, the laser transmitting plaque-remodeling laser energy to the at least one optical conduit in response to the imaging signals.

3. The catheter system of claim 2, wherein the laser comprises an ablation laser transmitting plaque-ablating laser energy.

4. The catheter system of claim 2, wherein the laser generates laser energy configured to effect at least one of remodeling of plaque, shrinkage of plaque, or melting of plaque.

5. The catheter system of claim 2, wherein the at least one window is radially oriented for imaging and remodeling of plaque eccentrically offset from the catheter relative to the axis.

6. The catheter system of claim 5, further comprising a first lens and a first mirror disposed along a first optical path between a distal end of the at least one conduit and the at least one window.

7. The catheter system of claim 6, further comprising a drive coupled to the proximal end of the catheter and a sleeve surrounding at least a portion of the optical conduit, the drive effecting scanning movement of the first optical path relative to the sleeve.

8. The catheter system of claim 7, wherein the drive comprises a rotational drive effecting rotation of the mirror about the axis, the imaging signals corresponding to rotational image scans.

9. The catheter system of claim 7, wherein a first optical fiber bundle directs the imaging light from the plaque to the tomographer and also directs the remodeling light toward the mirror.

10. The catheter system of claim 7, further comprising a second lens and a second mirror along a second optical path, wherein a first optical fiber bundle directs the imaging light from the plaque to the tomographer and a second optical fiber bundle directs the remodeling light toward the mirror.

11. The catheter system of claim 10, wherein the first and second optical paths adjacent the first and second mirrors are circumferentially offset.

12. The catheter system of claim 10, wherein the first and second optical paths adjacent the first and second mirrors are axially offset.

13. The catheter system of claim 10, wherein at least a portion of one of the optical paths surrounds the other optical path.

14. The catheter system of claim 2, wherein the laser energy has predetermined characteristics suitable for remodeling of atherosclerotic material.

15. The catheter system of claim 14, wherein the predetermined characteristics include one or more characteristic of the laser energy selected from the group comprising a frequency of the laser energy, a quantity of the laser energy, and a pattern of the laser energy.

16. The catheter system of claim 2, wherein the analyzer is configured to adjust at least one characteristic of the laser energy in response to the signals, the signals comprising feedback for remodeling of the atherosclerotic material.

35. The method of claim 3, wherein generating the signals comprises characterizing the plaque using frequencies of the optical energy, and wherein the transmitting of the remodeling energy selectively remodels the plaque in response to the tissue characterization.

17. A catheter system for removal of atherosclerotic material from a blood vessel of a patient, the system comprising:

an elongate flexible catheter having a proximal end and a distal end with an axis therebetween, the catheter having at least one laterally oriented window disposed proximal of the distal end for radial transmission of optical energy;

at least one optical conduit extending between the proximal end of the catheter and the at least one window;

a tissue analyzer coupled to the at least one optical conduit, the analyzer generating image signals using light from a plaque, the light transmitted through the at least one window and proximally along the at least one optical conduit; and

an ablation laser coupled to the analyzer, the ablation laser transmitting plaque-ablating laser energy to the at least one optical conduit in response to the imaging signals such that the plaque is ablated eccentrically relative to the axis.

18. A catheter system for remodeling of atherosclerotic material within a blood vessel of a patient, the system comprising:

an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having at least one laterally oriented window disposed proximal of the distal end for radial transmission of optical energy;

at least one optical conduit extending between the proximal end of the catheter and the at least one window;

a tissue analyzer coupled to the at least one optical conduit, the analyzer generating signals using light from a plaque, the light transmitted through the at least one window and proximally along the at least one optical conduit; and

a remodeling laser coupled to the analyzer, the remodeling laser transmitting plaque-remodeling laser energy to the at least one optical conduit in response to the signals such that the plaque is remodeled eccentrically relative to the axis.

19. The catheter system of claim 18, further comprising a laser coupled to the catheter for irradiating the plaque, wherein the analyzer comprises an optical coherence tomographer, wherein the signals comprise imaging signals, and wherein the system modulates the ablating laser energy in response to the imaging signals.

20. The catheter system of claim 18, further comprising a near-infrared light source coupled to the catheter for irradiating the plaque, wherein the analyzer comprises a reflectrometer, wherein the signals comprise tissue characterization signals, the system modulating the ablating laser energy in response to the tissue characterization signals.

21. The catheter system of claim 18, wherein the analyzer is configured to employ spectroscopy, wherein the signals comprise tissue characterization signals, the system modulating the ablating laser energy in response to the tissue characterization signals.

22. The catheter system of claim 21, wherein the analyzer is configured to employ Raman spectroscopy.

23. The catheter system of claim 18, wherein the analyzer is configured to characterize the tissue using frequency fingerprinting, and wherein the laser is energized in response to the signals so as to selectively remodel the plaque.

24. The catheter system of claim 18, further comprising a drive coupled to the catheter so as to effect scanning of an optical path of the laser energy from the at least one window, the analyzer configured to selectively energize the laser energy in response to the signals so as to inhibit injury to adjacent tissues.

25. The catheter system of claim 18, wherein the laser energy from the laser has a laser frequency within an energy absorbence frequency range of the plaque.

26. The catheter system of claim 18, wherein the analyzer is configured to characterize a state of the plaque or a temperature of the plaque.

27. The catheter system of claim 18, wherein the window transmits laser energy at a plurality of frequencies from the at least one window so as to remodel the plaque.

28. The catheter system of claim 18, wherein the analyzer is configured to determine a pattern of laser energy in response to the signals.

29. The catheter system of claim 18, wherein the laser energy has predetermined characteristics suitable for remodeling of atherosclerotic material.

30. The catheter system of claim 29, wherein the predetermined characteristics include one or more characteristic of the laser energy selected from the group comprising a frequency of the laser energy, a quantity of the laser energy, and a pattern of the laser energy.

31. The catheter system of claim 18, wherein the analyzer is configured to adjust at least one characteristic of the laser energy in response to the signals, the signals comprising feedback for remodeling of the atherosclerotic material.

32. A method comprising:

advancing a catheter into a blood vessel and positioning the catheter so that an axis of the catheter extends along an atherosclerotic plaque;

generating imaging signals from within the plaque using optical energy admitted radially into the catheter;

transmitting, in response to the imaging signals from within the plaque, plaque-ablating laser energy eccentrically from the catheter.

33. A method comprising:

advancing a catheter into a blood vessel and positioning the catheter so that an axis of the catheter extends along an atherosclerotic plaque;

generating signals from the plaque using optical energy admitted radially into the catheter;

transmitting, in response to the signals from within the plaque, plaque-remodeling laser energy eccentrically from the catheter.

34. The method of claim 33, wherein generating the signals comprises imaging the plaque by scanning an optical coherence tomographer rotationally, and wherein the laser energy is selectively directed eccentrically in response to the imaging signals.

36. The method of claim 33, further comprising determining characteristics of the laser energy has from prior laser irradiation of plaque so that the laser energy is suitable for remodeling of atherosclerotic material.

37. The method of claim 36, wherein the characteristics include one or more characteristic of the laser energy selected from the group comprising a frequency of the laser energy, a quantity of the laser energy, and a pattern of the laser energy.

38. The method of claim 33, further comprising adjusting at least one characteristic of the laser energy in response to the signals, the signals comprising feedback for remodeling of the atherosclerotic material.