Apparatus and methods for performing phototherapy, photodynamic therapy and diagnosis
First Claim
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1. A computer-controlled illumination system for phototherapy, photodynamic therapy and/or diagnosis, the system comprising:
- a tunable light source configured to emit illumination light comprising a variable selected spectral output and a variable selected wavelength dependent intensity distribution;
a sensor configured to detect light emanating from the tunable light source and transmit data representing at least the spectral output and wavelength dependent intensity distribution of the emanating light; and
a controller operably connected to the tunable light source and the sensor, the controller containing computer-implemented programming that is configured to coordinate the tunable light source, the sensor and the processor such that the programming varies the selected spectral output and wavelength dependent intensity distribution of the illumination light to provide a desired spectral output and wavelength dependent intensity distribution for at least one of the following procedures;
phototherapy, photodynamic therapy, and diagnosis.
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Abstract
Computer-controlled illumination systems that can be used to select a variety of wavelengths of light and intensities of such wavelengths suitable for the activation of various kinds of photodynamic drugs, for various types of phototherapy. If desired, the systems can work interactively with a measurement system to measure the quantity of some types of photodynamic drugs present in a tissue.
56 Citations
36 Claims
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1. A computer-controlled illumination system for phototherapy, photodynamic therapy and/or diagnosis, the system comprising:
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a tunable light source configured to emit illumination light comprising a variable selected spectral output and a variable selected wavelength dependent intensity distribution;
a sensor configured to detect light emanating from the tunable light source and transmit data representing at least the spectral output and wavelength dependent intensity distribution of the emanating light; and
a controller operably connected to the tunable light source and the sensor, the controller containing computer-implemented programming that is configured to coordinate the tunable light source, the sensor and the processor such that the programming varies the selected spectral output and wavelength dependent intensity distribution of the illumination light to provide a desired spectral output and wavelength dependent intensity distribution for at least one of the following procedures;
phototherapy, photodynamic therapy, and diagnosis. - View Dependent Claims (2, 3, 4, 6, 8, 9)
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5. (canceled)
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7. (canceled)
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10. (canceled)
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11. An endoscope system comprising:
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a computer-controlled illumination system comprising;
a tunable light source configured to emit illumination light comprising a variable selected spectral output and a variable wavelength dependent intensity distribution, a sensor configured to detect light emanating from the tunable light source and transmit a signal representing at least the spectral distribution and wavelength dependent intensity distribution of the emanating light to a processor, and a controller operably connected to the tunable light source, the sensor and the processor, the controller containing computer-implemented programming that is configured to coordinate the tunable light source, the sensor and the processor such that the programming varies the selected spectral output and wavelength dependent intensity distribution of the illumination light to provide a desired spectral output and wavelength dependent intensity distribution for at least one of the following procedures;
phototherapy, photodynamic therapy, and diagnosis; and
an endoscope body comprising a proximal end, a distal end and an illumination light guide, wherein the body is configured to position the distal end proximate to a target tissue, and the illumination guide is optically connectable to the computer-controlled illumination system to emit the illumination light from the distal end. - View Dependent Claims (12, 13, 14)
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15. A method for illuminating tissue for at least one of phototherapy, photodynamic therapy or diagnosis, the method comprising:
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generating an illumination light containing a desired variable spectral output and a desired variable wavelength dependent intensity distribution from a computer-controlled illumination system comprising;
a tunable light source configured to emit the illumination light, a detector configured to detect the illumination light and transmit data corresponding to the illumination light, and a controller operable to vary the a desired variable spectral output and a desired variable wavelength dependent intensity distribution of the illumination light;
detecting the illumination light with the detector; and
directing the illumination light toward a target tissue. - View Dependent Claims (17, 18, 19, 22, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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16. (canceled)
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20. (canceled)
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21. (canceled)
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23. (canceled)
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24. (canceled)
Specification