System and method for RF-induced hyperthermia
First Claim
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1. A non-invasive RF transceiver system for inducing hyperthermia in at least a portion of a target area, comprising:
- (a) an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator generating an RF signal at a frequency for transmission via the transmission head; and
(b) an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head; and
(c) wherein the transmission and reception heads are arranged proximate to and on either side of the target area so that the RF signal transmitted via the transmission head to the reception head passes through and warms at least a portion of the target area with neither of the heads being in direct contact with the portion of the target area being warmed.
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Abstract
An embodiment of a non-invasive RF system for inducing hyperthermia in a target area, and a corresponding non-invasive RF method for inducing hyperthermia in a target area are provided. The system includes an RF transmitter and transmission head, and RF receiver and reception head wherein the transmission and reception heads are arranged proximate a target area so that an RF signal between the heads induces hyperthermia in the target area. The method includes arranging the transmission head and reception head proximate and on either side of a target area and transmitting an RF signal through the target area.
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Citations
58 Claims
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1. A non-invasive RF transceiver system for inducing hyperthermia in at least a portion of a target area, comprising:
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(a) an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator generating an RF signal at a frequency for transmission via the transmission head; and
(b) an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head; and
(c) wherein the transmission and reception heads are arranged proximate to and on either side of the target area so that the RF signal transmitted via the transmission head to the reception head passes through and warms at least a portion of the target area with neither of the heads being in direct contact with the portion of the target area being warmed. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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14. A method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part, comprising the steps of:
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(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;
(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head;
(c) arranging the transmission and reception heads proximate to and on either side of the body part containing the target area in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least a portion of the target area with neither of the heads being in direct contact with the portion of the target area being warmed;
(d) insulating the transmission and reception heads from the body part;
(e) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the portion of the target area of the body part. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of inducing hyperthermia in at least a specific target portion of the target area of a patient'"'"'s body part, comprising the steps of:
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(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;
(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head, the reception head being selected from a plurality of heads having a shape and size selected in accordance with the shape and size of the specific target portion of the target area and placed in circuit communication with the resonant circuit;
(c) arranging the transmission and reception heads proximate to and on either side of the body part containing the specific target portion of the target area in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the specific target portion of the target area with neither of the heads being in contact with the body part, the reception head being positioned relative to the specific target portion of the target area in order to concentrate the RF signal through the specific target portion of the target area to warm at least the specific target portion of the target area;
(d) insulating the transmission and reception heads from the body part;
(e) providing antibodies bound to an RF absorption enhancer, wherein the antibodies bind to at least one type of cells within the specific target portion of the target area, to thereby increase the warming of the type of cells within the specific target portion of the target area by the RF signal;
(f) injecting the antibodies bound to the RF absorption enhancer into the patient;
(g) waiting for the antibodies bound to the RF absorption enhancer to bind to some of the at least one type of cells within the specific target portion of the target area; and
(h) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the specific target portion of the target area of the body part.
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29. A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:
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(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;
(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head;
(c) providing antibodies bound to an RF absorption enhancer, wherein the antibodies bind to the target cells to thereby increase the warming of the target cells by interaction between the RF signal and the RF absorption enhancer;
(d) injecting the antibodies bound to the RF absorption enhancer into the patient;
(e) waiting for the antibodies bound to the RF absorption enhancer to bind to some of the target cells; and
(f) arranging the transmission and reception heads proximate to and on either side of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the target cells with neither of the heads being in direct contact with the body part;
(g) insulating the transmission and reception heads from the body part; and
(h) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the target cells.
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30. A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:
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(a) extracting at least the target cells from the patient;
(b) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;
(c) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head;
(d) providing antibodies bound to an RF absorption enhancer, wherein the antibodies bind to the target cells to thereby increase the warming of the target cells by interaction between the RF signal and the RF absorption enhancer;
(e) exposing the target cells to the antibodies bound to the RF absorption enhancer;
(f) waiting for the antibodies bound to the RF absorption enhancer to bind to some of the target cells; and
(g) arranging the transmission and reception heads proximate to and on either side of a vessel containing at least the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the target cells; and
(h) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the target cells. - View Dependent Claims (31, 32, 33, 35)
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34. A method of separating target cells of a patient, comprising the steps of:
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(a) removing from the patient material containing at least the target cells;
(b) providing antibodies bound to a magnetic material, wherein the antibodies bind to the target cells;
(c) exposing the target cells to the antibodies bound to the magnetic material;
(d) waiting for the antibodies bound to the magnetic material to bind to some of the target cells; and
(e) providing a magnetic field to attract some of the target cells in such a manner to attract and thereby separate the target cells.
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36. A method of inducing hyperthermia in at least a specific target portion of the target area of a patient'"'"'s body part, comprising the steps of:
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(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;
(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head, the reception head comprising an electrical conductor for insertion into the patient in or near the specific target portion of the target area;
(c) inserting the electrical conductor into the patient in or near the specific target portion of the target area;
(d) arranging the transmission head proximate to the body part containing the specific target portion of the target area in such a manner that the RF signal transmitted via the transmission head to the reception head passes through at least a portion of and warms at least a portion of the specific target portion of the target area with the transmission head being insulated from contact with the body part;
(e) insulating the transmission head from the body part; and
(f) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming at least a portion of the specific target portion of the target area of the body part. - View Dependent Claims (37, 38)
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50. An RF system for inducing hyperthermia in a target area comprising:
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(a) an RF generator;
(b) a transmission head in circuit communication with the RF generator for transmitting at least one radio frequency; and
(c) a resonant circuit for receiving the radio frequency, wherein the resonant circuit is attached to cells in the target area and the cells in the target area are resonant at the transmitted radio frequency. - View Dependent Claims (51, 52, 53, 54)
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55. A method of inducing hyperthermia in cells in a target area comprising:
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(a) providing one or more resonant circuits;
(b) attaching the one or more resonant circuits to cells in the target area;
(c) providing a transmission head for transmitting the one or more radio frequencies;
(d) positioning the transmission head to transmit the one or more radio frequencies toward the one or more resonant circuits;
(e) transmitting the one or more radio frequencies toward the one or more resonant circuits; and
(f) causing the cells to be resonant while transmitting the one or more radio frequencies. - View Dependent Claims (56, 57, 58)
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Specification