System and method for RF-induced hyperthermia

• US 20050251233A1
• Filed: 10/20/2004
• Published: 11/10/2005
• Est. Priority Date: 05/07/2004
• Status: Abandoned Application

• Current Assignee: Akesogenx Corp.
• Original Assignee: Akesogenx Corp.
• Inventors: Kanzius, John
• Application Number:
  US10/969,477
• Publication Number:
  US 20050251233A1
• Time in Patent Office: Days
• US Class Current: 607/101
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61N 1/406 using implantable thermoseeds or injected particles for localized hyperthermia preparations of seeds and particles A61K41/0052

Abstract

An embodiment of a non-invasive RF system for inducing hyperthermia in a target area, and a corresponding non-invasive RF method for inducing hyperthermia in a target area are provided. The system includes an RF transmitter and transmission head, and RF receiver and reception head wherein the transmission and reception heads are arranged proximate a target area so that an RF signal between the heads induces hyperthermia in the target area. The method includes arranging the transmission head and reception head proximate and on either side of a target area and transmitting an RF signal through the target area.

Claims

1. A non-invasive RF transceiver system for inducing hyperthermia in at least a portion of a target area, comprising:

(a) an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator generating an RF signal at a frequency for transmission via the transmission head; and

(b) an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head; and

(c) wherein the transmission and reception heads are arranged proximate to and on either side of the target area so that the RF signal transmitted via the transmission head to the reception head passes through and warms at least a portion of the target area with neither of the heads being in direct contact with the portion of the target area being warmed.

2. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 1 wherein the transmission head to the reception head each comprise a plate of electrically conductive material.

3. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 1 wherein the resonant circuit is tuned to the frequency of the RF signal generated by the RF generator.

4. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 1 wherein the transmission and reception heads are insulated from the target area with sheets of electrically insulating material.

5. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 1 wherein the reception head is positioned relative to a specific target portion of the target area in order to concentrate the RF signal through the specific target portion of the target area to warm at least the specific target portion of the target area.

6. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 5 wherein the specific target portion of the target area has been injected with an RF absorption enhancer to increase the warming of the specific target portion of the target area by the RF signal.

7. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 5 wherein the specific target portion of the target area has been injected with an aqueous solution to increase the warming of the specific target portion of the target area by the RF signal.

8. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 5 wherein the specific target portion of the target area has been injected with a saline solution to increase the warming of the specific target portion of the target area by the RF signal.

9. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 5 wherein the specific target portion of the target area has been injected with an aqueous suspension of particles of an electrically conductive material to increase the warming of the specific target portion of the target area by the RF signal.

10. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 9 wherein the electrically conductive material comprises at least one metal.

11. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 5 wherein the specific target portion of the target area has been injected with an aqueous suspension of iron-containing particles to increase the warming of the specific target portion of the target area by the RF signal.

12. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 1 wherein the reception head is smaller in cross section than the transmission head and positioned relative to a specific target portion of the target area in order to concentrate the RF signal through the specific target portion of the target area to warm at least the specific target portion of the target area.

13. The non-invasive RF system for inducing hyperthermia in at least a portion of the target area according to claim 12 wherein the reception head is approximately the same shape in cross section as the specific target portion of the target area.

39. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein:

(a) the RF generator and the transmission head are configured and cooperate to permit the RF generator to generate and the transmission head to transmit a first RF signal at a first frequency and a second RF signal at a second frequency different than the first frequency; and

(b) the resonant circuit and the reception head are configured and cooperate to permit the reception head to receive the first RF signal at the first frequency and the second RF signal at the second frequency.

40. The non-invasive RF system for inducing hyperthermia according to claim 39 wherein the RF generator and the resonant circuit cooperate to alternate between the first frequency and the second frequency.

41. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein:

(a) the transmission head comprises at least first and second portions that are electrically insulated from each other to permit the first portion of the transmission head to transmit a first RF signal at a first frequency to further permit the second portion of the transmission head to transmit a second RF signal at a second frequency different than the first frequency;

(b) the RF generator is in circuit communication with the first and second portions of the transmission head;

(c) the reception head comprises at least first and second portions that are electrically insulated from each other to permit the first portion of the reception head to receive the first RF signal at the first frequency to further permit the second portion of the reception head to receive the second RF signal at the second frequency;

(d) the resonant circuit comprises at least first and second resonant circuit portions, each in circuit communication with one of the first and second portions of the reception head, the first and second resonant circuit portions being tuned to cause the first and second portions of the reception head to be resonant at the respective frequency of the respective RF signal transmitted via the respective portion of the transmission head so as to receive the respective RF signal transmitted via the respective portion of the transmission head; and

(e) the RF generator generates the first RF signal at the first frequency for transmission via the first portion of the transmission head and generates the second RF signal at the second frequency for transmission via the second portion of the transmission head.

42. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein the transmission and reception heads each comprise first and second portions that are electrically insulated from each other.

43. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein the transmission and reception heads are bumpy.

44. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein the transmission and reception heads each have a non-uniform thickness.

45. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein the transmission and reception heads are dimpled.

46. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein the amplitude of the RF signal is substantially constant.

47. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein the amplitude of the RF signal is varied.

48. The non-invasive RF system for inducing hyperthermia according to claim 1 wherein the amplitude of the RF signal is pulsed.

49. The non-invasive RF system for inducing hyperthermia according to claim 1 further comprising the step of cooling the patient'"'"'s blood in a device external to the patient.

14. A method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part, comprising the steps of:

(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;

(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head;

(c) arranging the transmission and reception heads proximate to and on either side of the body part containing the target area in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least a portion of the target area with neither of the heads being in direct contact with the portion of the target area being warmed;

(d) insulating the transmission and reception heads from the body part;

(e) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the portion of the target area of the body part.

15. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 14 wherein step (b), providing a resonant circuit in circuit communication with a reception head, comprises selecting the reception head from a plurality of heads of different sizes and placing the selected head in circuit communication with the resonant circuit.

16. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 14 wherein step (c), arranging the transmission and reception heads proximate to and on either side of the body part, comprises positioning the reception head relative to a specific target portion of the target area in order to concentrate the RF signal through the specific target portion of the target area to warm at least the specific target portion of the target area.

17. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein step (b), providing a resonant circuit in circuit communication with a reception head, comprises selecting the reception head from a plurality of heads and placing the selected reception head in circuit communication with the resonant circuit, and wherein the selected reception head is selected in accordance with the shape and size of the specific target portion of the target area.

18. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 14 wherein step (d), insulating the transmission and reception heads from the body part, comprises leaving an air gap between the transmission head and the skin of the body part and leaving an air gap between the reception head and the skin of the body part.

19. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 14 wherein step (d), insulating the transmission and reception heads from the body part, comprises inserting electrically insulating material between the transmission head and the body part and inserting a sheet of electrically insulating material between the reception head and the body part.

20. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein, prior to performing step (e), transmitting the RF signal at the frequency via the transmission head to the reception head, further performing the step of injecting the specific target portion of the target area with an RF absorption enhancer to increase the warming of the specific target portion of the target area by the RF signal.

21. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein, prior to performing step (e), transmitting the RF signal at the frequency via the transmission head to the reception head, further performing the step of injecting the specific target portion of the target area with an aqueous solution to increase the warming of the specific target portion of the target area by the RF signal.

22. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein, prior to performing step (e), transmitting the RF signal at the frequency via the transmission head to the reception head, further performing the step of injecting the specific target portion of the target area with a saline solution to increase the warming of the specific target portion of the target area by the RF signal.

23. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein, prior to performing step (e), transmitting the RF signal at the frequency via the transmission head to the reception head, further performing the step of injecting the specific target portion of the target area with an aqueous suspension of particles of an electrically conductive material to increase the warming of the specific target portion of the target area by the RF signal.

24. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 23 wherein the electrically conductive material comprises at least one metal.

25. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein, prior to performing step (e), transmitting the RF signal at the frequency via the transmission head to the reception head, further performing the step of injecting the specific target portion of the target area with an aqueous suspension of iron-containing particles to increase the warming of the specific target portion of the target area by the RF signal.

26. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein, prior to performing step (e), transmitting the RF signal at the frequency via the transmission head to the reception head, further performing the step of injecting the specific target portion of the target area with particles that increase the warming of the specific target portion of the target area by the RF signal.

27. The method of inducing hyperthermia in at least a portion of the target area of a patient'"'"'s body part according to claim 16 wherein, prior to performing step (e), transmitting the RF signal at the frequency via the transmission head to the reception head, further performing the step of injecting the patient with antibodies bound to an RF absorption enhancer, wherein the antibodies bind to at least one type of cells within the specific target portion of the target area, to thereby increase the warming of the type of cells within the specific target portion of the target area by the RF signal.

28. A method of inducing hyperthermia in at least a specific target portion of the target area of a patient'"'"'s body part, comprising the steps of:

(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;

(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head, the reception head being selected from a plurality of heads having a shape and size selected in accordance with the shape and size of the specific target portion of the target area and placed in circuit communication with the resonant circuit;

(c) arranging the transmission and reception heads proximate to and on either side of the body part containing the specific target portion of the target area in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the specific target portion of the target area with neither of the heads being in contact with the body part, the reception head being positioned relative to the specific target portion of the target area in order to concentrate the RF signal through the specific target portion of the target area to warm at least the specific target portion of the target area;

(d) insulating the transmission and reception heads from the body part;

(e) providing antibodies bound to an RF absorption enhancer, wherein the antibodies bind to at least one type of cells within the specific target portion of the target area, to thereby increase the warming of the type of cells within the specific target portion of the target area by the RF signal;

(f) injecting the antibodies bound to the RF absorption enhancer into the patient;

(g) waiting for the antibodies bound to the RF absorption enhancer to bind to some of the at least one type of cells within the specific target portion of the target area; and

(h) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the specific target portion of the target area of the body part.

29. A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;

(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head;

(c) providing antibodies bound to an RF absorption enhancer, wherein the antibodies bind to the target cells to thereby increase the warming of the target cells by interaction between the RF signal and the RF absorption enhancer;

(d) injecting the antibodies bound to the RF absorption enhancer into the patient;

(e) waiting for the antibodies bound to the RF absorption enhancer to bind to some of the target cells; and

(f) arranging the transmission and reception heads proximate to and on either side of at least one body part of the patient containing the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the target cells with neither of the heads being in direct contact with the body part;

(g) insulating the transmission and reception heads from the body part; and

(h) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the target cells.

30. A method of inducing hyperthermia in at least target cells of a patient, comprising the steps of:

(a) extracting at least the target cells from the patient;

(b) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;

(c) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head;

(d) providing antibodies bound to an RF absorption enhancer, wherein the antibodies bind to the target cells to thereby increase the warming of the target cells by interaction between the RF signal and the RF absorption enhancer;

(e) exposing the target cells to the antibodies bound to the RF absorption enhancer;

(f) waiting for the antibodies bound to the RF absorption enhancer to bind to some of the target cells; and

(g) arranging the transmission and reception heads proximate to and on either side of a vessel containing at least the target cells in such a manner that the RF signal transmitted via the transmission head to the reception head passes through and warms at least the target cells; and

(h) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming the target cells.

31. The method of inducing hyperthermia in at least target cells of a patient according to claim 30 wherein step (a), extracting at least the target cells from the patient, comprises the steps of:

(a) removing from the patient material containing at least the target cells;

(b) providing antibodies bound to a magnetic material, wherein the antibodies bind to the target cells;

(c) exposing the target cells to the antibodies bound to the magnetic material;

(d) waiting for the antibodies bound to the magnetic material to bind to some of the target cells; and

(e) providing a magnetic field to attract some of the target cells in such a manner to attract and thereby separate the target cells.

32. The method of inducing hyperthermia in at least target cells of a patient according to claim 31 wherein step (c), exposing the target cells to the antibodies bound to the magnetic material, is performed after step (a), removing from the patient material containing at least the target cells.

33. The method of inducing hyperthermia in at least target cells of a patient according to claim 31 wherein step (c), exposing the target cells to the antibodies bound to the magnetic material, is performed before step (a), removing from the patient material containing at least the target cells.

35. The method of separating target cells of a patient according to claim 31 wherein the target cells are in the patient'"'"'s blood and further comprising the step of placing the patient'"'"'s blood in a vessel, and further wherein step (e), providing a magnetic field to attract some of the target cells in such a manner to attract and thereby separate the target cells, comprises the step of generating a magnetic field aligned with respect to the vessel to attract and thereby separate the target cells from other blood components.

34. A method of separating target cells of a patient, comprising the steps of:

(a) removing from the patient material containing at least the target cells;

(b) providing antibodies bound to a magnetic material, wherein the antibodies bind to the target cells;

(c) exposing the target cells to the antibodies bound to the magnetic material;

(d) waiting for the antibodies bound to the magnetic material to bind to some of the target cells; and

(e) providing a magnetic field to attract some of the target cells in such a manner to attract and thereby separate the target cells.

36. A method of inducing hyperthermia in at least a specific target portion of the target area of a patient'"'"'s body part, comprising the steps of:

(a) providing an RF transmitter having an RF generator in circuit communication with a transmission head, the RF generator capable of generating an RF signal at a frequency for transmission via the transmission head;

(b) providing an RF receiver having a resonant circuit in circuit communication with a reception head, the resonant circuit being tuned to cause at least a portion of the reception head to be resonant at the frequency of the RF signal transmitted via the transmission head so as to receive the RF signal transmitted via the transmission head, the reception head comprising an electrical conductor for insertion into the patient in or near the specific target portion of the target area;

(c) inserting the electrical conductor into the patient in or near the specific target portion of the target area;

(d) arranging the transmission head proximate to the body part containing the specific target portion of the target area in such a manner that the RF signal transmitted via the transmission head to the reception head passes through at least a portion of and warms at least a portion of the specific target portion of the target area with the transmission head being insulated from contact with the body part;

(e) insulating the transmission head from the body part; and

(f) transmitting the RF signal at the frequency via the transmission head to the reception head, thereby warming at least a portion of the specific target portion of the target area of the body part.

37. The method of inducing hyperthermia in at least a specific target portion of the target area of a patient'"'"'s body part according to claim 36, wherein prior to transmitting the RF signal, further comprising the steps of:

(a) providing antibodies bound to an RF absorption enhancer, wherein the antibodies bind to at least one type of cells within the specific target portion of the target area, to thereby increase the warming of the type of cells within the specific target portion of the target area by the RF signal;

(b) injecting the antibodies bound to the RF absorption enhancer into the patient; and

(c) waiting for the antibodies bound to the RF absorption enhancer to bind to some of the at least one type of cells within the specific target portion of the target area.

38. The method of inducing hyperthermia in at least a specific target portion of the target area of a patient'"'"'s body part according to claim 36, wherein prior to transmitting the RF signal, further comprising the steps of:

(a) providing antibodies bound to an electrical conductor, wherein the antibodies bind to at least one type of cells within the specific target portion of the target area, to thereby permit at least a portion specific target portion of the target area to help function as the reception head;

(b) injecting the antibodies bound to the electrical conductor into the patient; and

(c) waiting for the antibodies bound to the electrical conductor to bind to some of the at least one type of cells within the specific target portion of the target area.

50. An RF system for inducing hyperthermia in a target area comprising:

(a) an RF generator;

(b) a transmission head in circuit communication with the RF generator for transmitting at least one radio frequency; and

(c) a resonant circuit for receiving the radio frequency, wherein the resonant circuit is attached to cells in the target area and the cells in the target area are resonant at the transmitted radio frequency.

51. The RF system for inducing hyperthermia of claim 50 wherein the resonant circuit is attached to the cells in the target area via a needle.

52. The RF system for inducing hyperthermia of claim 51 wherein the needle comprises one or more extension members.

53. The RF system for inducing hyperthermia of claim 50 wherein the resonant circuit is attached to the cells in the target area by a carrier mechanism.

54. The RF system for inducing hyperthermia of claim 53 wherein the carrier mechanism is one or more antibodies.

55. A method of inducing hyperthermia in cells in a target area comprising:

(a) providing one or more resonant circuits;

(b) attaching the one or more resonant circuits to cells in the target area;

(c) providing a transmission head for transmitting the one or more radio frequencies;

(d) positioning the transmission head to transmit the one or more radio frequencies toward the one or more resonant circuits;

(e) transmitting the one or more radio frequencies toward the one or more resonant circuits; and

(f) causing the cells to be resonant while transmitting the one or more radio frequencies.

56. The method of inducing hyperthermia in cells in the target area of claim 55 wherein the step of attaching the one or more resonant circuits to the cells in the target area comprises inserting a needle into the target area.

57. The method of inducing hyperthermia in cells in the target area of claim 55 wherein attaching the one or more resonant circuits to the cells in the target area comprises attaching the one or more resonant circuits to one or more carrier mechanisms.

58. The method of inducing hyperthermia in cells in the target area of claim 57 wherein the one or more carrier mechanisms comprises one or more antibodies.