Non-thrombogenic stent jacket

• US 20050251244A1
• Filed: 07/15/2005
• Published: 11/10/2005
• Est. Priority Date: 09/23/1997
• Status: Active Grant

• Current Assignee: Amnis Therapeutics Ltd.
• Original Assignee: Design & Performance-Cyprus Limited
• Inventors: Vonderwalde, Carlos
• Granted Patent: US 8,882,822 B2
• Time in Patent Office: Days
• US Class Current: 623/1.120
• CPC Class Codes: A61F 2/062 Apparatus for the production of blood vessels made from natural tissue or with layers of living cells prostheses made from natural tissue or living cells A61L27/507
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

Disclosed is the use of serous tissue, such as pericardium, as a component of intracorporeal implants. Particularly, disclosed is a jacketed stent assembly comprising an expandable stent provided with a jacket of processed serous tissue which, in some embodiments, is impregnated with a therapeutic or diagnostic agent. In a preferred embodiment, the jacket of the expandable stent is formed of pericardial tissue, preferably bovine or porcine pericardial tissue.

Claims

1. A stent assembly, comprising:

a. an expandable stent; and

b. functionally associated with said expandable stent, a stent jacket substantially of a processed serous membrane including a serous tissue stratum and a basement tissue stratum, wherein said processed serous membrane has been processed by removal of a layer of basement tissue from a harvested serous membrane.

2. The stent assembly of claim 1, wherein said jacket is fit about the outer surface of said expandable stent.

3. The stent assembly of claim 1, wherein said jacket is fit on the inner surface of said expandable stent.

4. The stent assembly of claim 1, further comprising a therapeutic or diagnostic agent releasably contained within said stent jacket.

5. A stent assembly, comprising:

a. an expandable stent; and

b. functionally associated with said expandable stent, a stent jacket essentially consisting of a serous tissue layer substantially devoid of a basement tissue layer.

6. The stent assembly of claim 5, wherein said jacket is fit about the outer surface of said expandable stent.

7. The stent assembly of claim 5, wherein said jacket is fit on the inner surface of said expandable stent.

8. The stent assembly of claim 5, further comprising a therapeutic or diagnostic agent releasably contained within said stent jacket.

9. The use of a processed serous membrane including a serous tissue stratum and a basement tissue stratum as a component of a stent assembly including an expandable stent wherein said processed serous membrane has been processed by removal of a layer of basement tissue from a harvested serous membrane.

10. The use of claim 9, wherein said processed serous membrane is a jacket fit on the inner surface of said expandable stent.

11. The use of claim 9, wherein said processed serous membrane is a jacket fit about the outer surface of said expandable stent.

12. The use of a serous tissue layer substantially devoid of a basement tissue layer as a component of a stent assembly including an expandable stent.

13. The use of claim 12, wherein said serous tissue layer is a jacket fit on the inner surface of said expandable stent.

14. The use of claim 12, wherein said serous tissue layer is a jacket fit about the outer surface of said expandable stent.

15. A method of producing a stent assembly, comprising:

a. providing a sheet of serous membrane including a serous tissue stratum and a basement tissue stratum;

b. thinning said sheet of serous membrane by removing a layer of said basement tissue stratum thereby making a sheet of thinned serous membrane;

c. associating said sheet of thinned serous membrane with an expandable stent, thereby producing the stent assembly.

16. The method of claim 15, wherein said thinning is of the entire said basement tissue stratum.

17. The method of claim 15, wherein said thinning is effected by at least one method selected from the group consisting of peeling and shaving.

18. The method of claim 15, wherein said associating includes wrapping said sheet about said expandable stent.

19. The method of claim 15, wherein said associating includes fitting said processed serous membrane the inner surface of said expandable stent.

20. The method of claim 15, further comprising:

d. impregnating said sheet of serous membrane with a liquid containing a therapeutic or diagnostic agent.