Fluorescence diagnostic system

• US 20050253087A1
• Filed: 08/01/2002
• Published: 11/17/2005
• Est. Priority Date: 08/09/2001
• Status: Abandoned Application

• Current Assignee: BIOCAM GmbH
• Original Assignee: BIOCAM GmbH
• Inventors: Plan, Thomas
• Application Number:
  US10/485,256
• Publication Number:
  US 20050253087A1
• Time in Patent Office: Days
• US Class Current: 250/458.100
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/6456 Spatial resolved fluorescence measurements; Imaging

Abstract

The invention refers to a new system for the fluorescent diagnosis of organs or tissues, with at least one light source for providing an excitation light to an examination area and with an optical detector for fluorescence, which due to the excitation light is produced by a fluorescent dye present in the tissue.

Claims

1-14. -14. (canceled)

15. A system for the fluorescent diagnosis of organs and tissues with at least one excitation light source for providing an excitation light to an examination area for a fluorescence, which due to the excitation light is produced by a fluorescent dye present in the tissue, with a camera system for generating a fluorescent image of the examination area using the excitation light and a normal image of the examination area, wherein the camera system has a single opto-electric image converter both for generating the fluorescent image and for generating the normal image under ambient light, and that the excitation light source is a pulsed light source, the light of which is superimposed by the ambient light for the normal image.

16. The system as claimed in claim 15, wherein the normal image and the fluorescent image of the examination area are generated successively in time, the fluorescent image during an excitation and fluorescence phase, in which the at least one excitation light source for emitting the excitation light is activated, and the normal image outside of the excitation and fluorescence phase.

17. The system as claimed in claim 15, further comprising a first electronic control unit for the camera system or the opto-electric image converter.

18. The system as claimed in claim 17, wherein the opto-electric image converter has an RGB output, and the first electronic control unit for generating the fluorescent image analyzes only image signals present at the output of the opto-electric image converter corresponding to the spectral range of the fluorescent image.

19. The system as claimed in claim 17, wherein the electronic control unit receives the image signals generated by the opto-electric image converter as image signals of the fluorescent image synchronously with the activation of the at least one excitation light source, generating images for further image processing.

20. The system as claimed in claim 15, further comprising a second electronic control unit for the at least one excitation light source.

21. The system as claimed in claim 20, further comprising at least one excitation light source and/or the second electronic control unit are triggered by the first electronic control unit.

22. The system as claimed in claim 15, further comprising means for injecting the excitation light of the at least one pulsed excitation light source into the beam path or into the optical axis of the at least one camera system.

23. The system as claimed in claim 22, wherein the means for injecting the excitation light comprises at least one splitter mirror.

24. The system as claimed in claim 15, wherein the opto-electric image converter is a CCD chip.

25. The system as claimed in claim 15, wherein the electronic control unit analyzes the signal of the R-channel of the opto-electric image converter.

26. The system as claimed in claim 15, wherein the spectrum of light of the pulsed light source is in the visible spectral range and/or in the infrared range and/or in the UV range.