Low coherence interferometric system for optical metrology

• US 20050254059A1
• Filed: 05/14/2004
• Published: 11/17/2005
• Est. Priority Date: 05/14/2004
• Status: Abandoned Application

• Current Assignee: VZN Capital, LLC
• Original Assignee: VZN Capital, LLC
• Inventors: Alphonse, Gerard A.
• Application Number:
  US10/846,445
• Publication Number:
  US 20050254059A1
• Time in Patent Office: Days
• US Class Current: 356/479
• CPC Class Codes: A61B 2560/0233 Optical standards
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

A system for optical metrology of a biological sample comprising: a broadband light source; an optical assembly receptive to the broadband light, the optical assembly configured to facilitate transmission of the broadband light in a first direction and impede transmission of the broadband light a second direction; a sensing light path receptive to the broadband light from the optical assembly; a fixed reflecting device; a reference light path receptive to the broadband light from the optical assembly, the reference light path coupled with the sensing light path, the reference light path having an effective light path length longer than an effective light path length of the sensing light path by a selected length corresponding to about a selected target depth within the biological sample; and a detector receptive the broadband light resulting from interference of the broadband light to provide an electrical interference signal indicative thereof.

Claims

1. A system for optical metrology of a biological sample, said system comprising:

a broadband light source for providing a broadband light;

an optical assembly receptive to said broadband light, said optical assembly configured to facilitate transmission of said broadband light in a first direction and impede transmission of said broadband light a second direction, said optical assembly generally maintaining low coherence of said broadband light;

a sensing light path receptive to said broadband light from said optical assembly, said sensing light path configured to direct said broadband light at the biological sample and to receive said broadband light reflected from the biological sample;

a fixed reflecting device;

a reference light path receptive to said broadband light from said optical assembly, said reference light path configured to direct said broadband light at said fixed reflecting device and to receive said broadband light reflected from said fixed reflecting device, said reference light path coupled with said sensing light path to facilitate interference of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device, said reference light path having an effective light path length longer than an effective light path length of said sensing light path by a selected length corresponding to about a selected target depth within the biological sample; and

a detector receptive said broadband light resulting from interference of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device to provide an electrical interference signal indicative thereof.

2. The system of claim 1 wherein:

said broadband light has a first polarization; and

said optical assembly comprises,

a beam splitter configured to facilitate transmission of said broadband light received from said broadband light source in said first direction based said first polarization, said first direction being from said broadband light source, said beam splitter further configured to impede transmission of said broadband light resulting from interference of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device in said second direction based on a second polarization, said second direction being towards said broadband light source, and

a quarter-wave plate receptive to said broadband light resulting from interference of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device, said quarter-wave plate configured to induce said second polarization on said broadband light resulting from interference of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device.

3. The system of claim 2 wherein said beam splitter is further configured to facilitate transmission of said broadband light resulting from interference of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device in a third direction based on said second polarization, said third direction being toward said detector, said beam splitter further configured to impede transmission of said broadband light received from said broadband light source in said third direction based said first polarization.

4. The system of claim 2 wherein said quarter-wave plate is further receptive to said broadband light transmitted from said beam splitter, said quarter-wave plate is configured to induce a third polarization on said broadband light transmitted from said beam splitter.

5. The system of claim 2 wherein said first polarization comprises one of horizontal polarization and vertical polarization, and said second polarization is another of said horizontal polarization and said vertical polarization.

6. The system of claim 1 wherein said optical assembly impedes transmission of said broadband light to less than or equal to about 10⁻

3.

7. The system of claim 6 wherein said optical assembly impedes transmission of said broadband light to less than or equal to about 10⁻

4.

8. The system of claim 1 wherein:

said broadband light has a first polarization; and

said optical assembly comprises,

an isolator configured to facilitate transmission of said broadband light received from said broadband light source in said first direction based said first polarization, said first direction being from said broadband light source, said isolator further configured to impede transmission of said broadband light resulting from interference of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device in said second direction based on a second polarization, said second direction being towards said broadband light source.

9. The system of claim 1 wherein said broadband light source comprises a super-luminescent diode.

10. The system of claim 1 wherein said optical assembly generally maintains an output power level of said broadband light.

11. The system of claim 1 wherein said reference light path coupled with said sensing light path comprises a splitter/combiner.

12. The system of claim 1 wherein at least one of said sensing light path and said reference light path are comprised of at least one of an optical fiber and a waveguide.

13. The system of claim 12 further comprising a substrate having said waveguide formed therein by thermal diffusion of metal ions evaporated through masks having a width for single transverse-mode operation.

14. The system of claim 13 wherein said metal increases an index of refraction of said substrate.

15. The system of claim 14 wherein said metal comprises titanium.

16. The system of claim 12 wherein said waveguide is formed by annealed proton exchange in an acid bath.

17. The system of claim 12 wherein said substrate is substantially comprised of lithium niobate.

18. The system of claim 12 wherein said substrate is substantially comprised of at least one of lithium tantalite and indium phosphide.

19. The system of claim 12 wherein said at least one of said optical fiber and said waveguide are configured for single transverse-mode transmission.

20. The system of claim 12 wherein said at least one of said optical fiber and said waveguide are configured to maintain polarization of said broadband light therein.

21. The system of claim 12 wherein said at least one of an optical fiber and an optical waveguide are configured to minimize reflection.

22. The system of claim 1 further comprising a modulator associated with at least one of said reference light path and said sensing light path for manipulating said effective light path length thereof.

23. The system of claim 22 wherein said modulator comprises metallic electrodes deposited at said at least one of said waveguide reference light path and said waveguide sensing light path.

24. The system of claim 22 wherein said modulator comprises an optical fiber circumferentially wound around a piezoelectric drum, wherein said piezoelectric drum increases a length of said optical fiber upon application of a voltage to said piezoelectric drum and thereby increasing said effective light path length thereof.

25. The system of claim 1 further comprising a calibration strip having a known refractive index.

26. The system of claim 1 further comprising a processing system in operable communication with said detector, said processing system configured for processing said electrical interference signal.

27. The system of claim 26 said processing system further configured for controlling said system.

28. The system of claim 26 wherein said processing system is, at least in part, packaged integral with the rest of said system.

29. The system of claim 26 wherein said processing system includes a controller and an associated display.

30. The system of claim 1 wherein said system is configured and packaged as a portable instrument.

31. The system of claim 30 wherein said portable instrument has a volume less than about 0.5 cubic feet.

32. The system of claim 30 wherein said system is configured and packaged as a handheld instrument.

33. The system of claim 32 wherein said handheld instrument has a volume of less than about 24 cubic inches.

34. The system of claim 33 wherein said handheld instrument has a volume of less than about 4 cubic inches.

35. The system of claim 1 wherein said system is modular with a handheld measurement part and a remote processing part.

36. The system of claim 1 wherein said system is configured to interface with a remote system.

37. The system of claim 1 further comprising an extension module to extend said reference light path and said sensing light path.

38. The system of claim 37 wherein said extension module includes a modulator for manipulating at least one of said effective light path length of said reference light path and said effective light path length of said sensing light path.

39. The system of claim 37 wherein said modulator comprises an optical fiber circumferentially wound around a piezoelectric drum, wherein said piezoelectric drum increases a length of said optical fiber upon application of a voltage to said piezoelectric drum and thereby increasing said effective light path length thereof.

40. The system of claim 39 wherein said optical fiber comprises a polarization-maintaining optical fiber.

41. The system of claim 38 wherein said fixed reflecting device is disposed at said extension module with extended said reference light path terminating thereat, and said extension module further including an optical fiber probe to extend said sensing light path.

42. The system of claim 12 wherein said optical fiber includes an antireflective coating at a distal end thereof.

43. The system of claim 1 further comprising a thermoelectric cooler associated with said broadband light source to maintain a temperature thereof below a threshold.

44. The system of claim 1 wherein said system is configured to be a modular system.

45. The system of claim 1 wherein said modular system includes:

a first module including said broadband light source, said optical assembly, and said detector; and

a second module including said sensing light path, said fixed reflecting device, and said reference light path.

61. The method of claim 40 further comprising processing said electrical interference signal.

46. A method for optical metrology of a biological sample, the method comprising:

providing a broadband light by means of a broadband light source;

facilitating transmission of said broadband light in a first direction and impeding transmission of said broadband light a second direction, while generally maintaining low coherence of said broadband light;

directing said broadband light by means of a sensing light path at the biological sample, said sensing light path having an effective light path length;

receiving said broadband light reflected from the biological sample by means of said sensing light path;

directing said broadband light by means of a reference light path at a fixed reflecting device, said reference light path having an effective light path length, said effective light path length of said reference light path being longer than said effective light path length of said sensing light path by a selected length corresponding to about a selected target depth within the biological sample;

receiving said broadband light reflected from said fixed reflecting device by means of said reference light path;

interfering said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device; and

detecting said broadband light resulting from interference of said broadband light reflected from the biological sample and said broadband light reflected from said reflecting device to provide an electrical interference signal indicative thereof.

47. The method of claim 46 wherein:

said broadband light has a first polarization;

said facilitating transmission of said broadband light comprises facilitating transmission of said broadband light from said broadband light source in said first direction based said first polarization, said first direction being from said broadband light source; and

said impeding transmission of said broadband light comprises impeding transmission of said broadband light resulting from said interfering of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device in said second direction based on a second polarization, said second direction being towards said broadband light source.

48. The method of claim 47 further comprising:

inducing said second polarization on said broadband light resulting from said interfering of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device.

49. The method of claim 48 wherein:

said facilitating transmission of said broadband light further comprises facilitating transmission of said broadband light resulting from said interfering of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device in a third direction based on said second polarization, said third direction being toward a detector for said detecting; and

said impeding transmission of said broadband light further comprises impeding transmission of said broadband light received from said broadband light source in said third direction based said first polarization.

50. The method of claim 48 further comprising:

inducing a third polarization on said broadband light transmitted resulting from said interfering of said broadband light reflected from the biological sample and said broadband light reflected from said fixed reflecting device.

51. The method of claim 48 wherein said first polarization comprises one of horizontal polarization and vertical polarization, and said second polarization is another of said horizontal polarization and said vertical polarization.

52. The method of claim 46 wherein said impeding transmission of said broadband light comprises impeding to less than or equal to about 10⁻

3.

53. The method of claim 52 wherein said impeding transmission of said broadband light comprises impeding to less than or equal to about 10⁻

4.

54. The method of claim 46 wherein said broadband light source comprises a super-luminescent diode.

55. The method of claim 46 wherein said facilitating transmission of said broadband light in said first direction and said impeding transmission of said broadband light said second direction, further comprises while generally maintaining an output power level of said broadband light.

56. The method of claim 46 wherein at least one of said sensing light path and said reference light path are comprised of at least one of an optical fiber and a waveguide.

57. The method of claim 56 further comprising maintaining polarization of said broadband light in said at least one of said optical fiber and said waveguide.

58. The method of claim 56 further comprising minimizing reflection in said at least one of an optical fiber and an optical waveguide.

59. The method of claim 46 further comprising:

modulating said effective light path length of at least one of said reference light path and said sensing light path.

60. The method of claim 46 further comprising calibrating relative to a known refractive index.

62. The method of claim 46 further comprising interfacing said electrical interference signal with a remote system.

63. The method of claim 46 further comprising extending said reference light path and said sensing light path.

64. The method of claim 46 further comprising maintaining generally a temperature of said broadband light source below a threshold.