System for amplifying optical detection of cantilever deflection

• US 20050255448A1
• Filed: 07/06/2004
• Published: 11/17/2005
• Est. Priority Date: 05/13/2004
• Status: Abandoned Application

• Current Assignee: Rogents of The University of California
• Original Assignee: Rogents of The University of California
• Inventors: Majumdar, Arun, Satyanarayana, Srinath
• Application Number:
  US10/883,964
• Publication Number:
  US 20050255448A1
• Time in Patent Office: Days
• US Class Current: 435/4
• CPC Class Codes: B82Y 35/00 Methods or apparatus for measurement or analysis of nanostructures
• CPC Class Codes: G01N 2291/0256 Adsorption, desorption, surface mass change, e.g. on biosensors
• CPC Class Codes: G01N 29/036 by measuring frequency or resonance of acoustic waves

Abstract

A sensor system configured to amplify cantilever deflection, having: a reflective membrane connected to a cantilever, wherein the reflective membrane rotates more than the cantilever when the cantilever deflects. A sensor system, including: a cantilever having a first end and a second end, the first end being held at a first fixed location and the second end being free to move; and a reflective membrane having a first end and a second end, the first end being held at a second fixed location and the second end being attached to the cantilever.

Claims

1. A sensor system, comprising:

a cantilever having a first end and a second end, the first end being held at a first fixed location and the second end being free to move; and

a reflective membrane having a first end and a second end, the first end being held at a second fixed location and the second end being attached to the cantilever.

2. The system of claim 1, wherein the reflective membrane comprises:

a layer of reflective material disposed on the reflective membrane.

3. The system of claim 1, wherein the reflective membrane comprises:

a panel of reflective material attached to the reflective membrane.

4. The system of claim 1, wherein a first portion of the reflective membrane is reflective, and a second portion of the reflective membrane is not reflective.

5. The system of claim 1, wherein the cantilever is longer than the reflective membrane.

6. The system of claim 1, further comprising:

a substrate, wherein the first end of the reflective membrane is attached to the substrate; and

a wall, wherein both the substrate and the cantilever are attached to the wall, and wherein the substrate and the cantilever extend in the same direction away from the wall.

7. The system of claim 6, wherein the substrate and the cantilever are generally parallel to one another prior to cantilever deflection.

8. The system of claim 1, wherein deflection of the cantilever causes rotation of the reflective membrane.

9. The system of claim 8, wherein the angle to which the reflective membrane rotates is greater than the angle to which the portion of the cantilever to which the second end of the reflective membrane is attached rotates.

10. The system of claim 1, wherein the angle of rotation of the reflective membrane is greater than the angle of rotation of the second end of the cantilever when the cantilever deflects.

11. The system of claim 1, wherein the reflecting membrane comprises:

a pair of membrane strips with a panel of reflective material disposed thereacross.

12. The system of claim 1, wherein the cantilever has probe molecules or cells disposed thereon.

13. The system of claim 12, wherein the cantilever deflects in response to target molecules or cells interacting with the probe molecules or cells.

23. The sensor system of claim 1, wherein the cantilever is stiffer than the reflective membrane.

14. A sensor system configured to amplify cantilever deflection, comprising:

a reflective membrane connected to a cantilever, wherein the reflective membrane rotates more than the cantilever when the cantilever deflects.

15. The sensor system of claim 14, wherein the reflective membrane rotates more than the portion of the cantilever connected to the reflective membrane when the cantilever deflects.

16. The system of claim 15, wherein the cantilever is longer than the reflective membrane.

17. The system of claim 16, wherein the cantilever has a first end and a second end, the first end being held at a fixed location and the second end being free to move, and wherein the reflective membrane has a first end and a second end, the first end being held at a fixed location and the second end being attached to the cantilever.

18. A method of sensing cantilever deflection, comprising:

directing a beam of incident light towards a reflective membrane, wherein a first end of the reflective membrane is held at a fixed location and a second end of the reflective membrane is attached to a cantilever;

deflecting the cantilever; and

detecting movement of a beam of light reflected by the reflective membrane.

19. The method of claim 18, wherein the cantilever is longer than the reflective membrane.

20. The method of claim 18, wherein deflecting the cantilever comprises:

exposing the cantilever to target molecules or cells, wherein the cantilever deflects in response to the target molecules or cells interacting with probe molecules or cells disposed on the cantilever.

21. The method of claim 20, wherein detecting the movement of the beam of light reflected by the reflective membrane corresponds to determining target molecule or cell concentration.

22. The method of claim 18, wherein the angle to which the reflective membrane rotates is greater than the angle to which the cantilever rotates.

24. A deflectable two-part sensor, comprising:

a first part being stiff which deflects in response to bonding thereon; and

a second part being compliant and optically reflective, wherein the first and second parts are connected together such that deflection of the first part results in amplification of the deflection of the second part.

25. The sensor of claim 24, wherein the first part is a functionalized cantilever, and the second part is a reflective membrane attached thereto.

26. The sensor of claim 24, wherein one end of each of the first and second parts of the sensor are supported at fixed locations.

27. The sensor of claim 24, wherein the first part of the sensor is longer than the second part of the sensor.

28. The sensor of claim 24, wherein the first and second parts are connected together such that rotation of the first part results in amplification of the rotation of the second part.