Protein scaffolds for antibody mimics and other binding proteins
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Abstract
Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.
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Citations
88 Claims
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1-67. -67. (canceled)
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68. A protein comprising:
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(a) a first fibronectin type III (Fn3) domain wherein said first Fn3 domain has an amino acid sequence that has been altered relative to the amino acid sequence of a first naturally occurring Fn3 domain such that the first Fn3 domain binds to a first compound that is not bound by the first naturally occurring Fn3 domain; and
(b) a second Fn3 domain, wherein said second Fn3 domain has an amino acid sequence that has been altered relative to the amino acid sequence of a second naturally occurring Fn3 domain such that the second Fn3 domain binds to a compound that is not bound by the second naturally occurring Fn3 domain. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88)
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Specification