Apparatus and method for transdermal delivery of parathyroid hormone agents
First Claim
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1. A device for transdermally delivering a PTH-based agent to a patient, comprising:
- a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a biocompatible coating disposed on said microprojection member, said coating being formed from a coating formulation having at least one PTH-based agent disposed thereon.
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Abstract
An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
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Citations
86 Claims
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1. A device for transdermally delivering a PTH-based agent to a patient, comprising:
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a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a biocompatible coating disposed on said microprojection member, said coating being formed from a coating formulation having at least one PTH-based agent disposed thereon. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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72. A method of transdermally delivering a PTH-based agent to a patient, comprising the steps of:
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providing a microprojection member having a plurality of stratum corneum-piercing microprotrusions, said microprotrusion member having a coating disposed thereon, said coating including at least one PTH-based agent;
applying said microprojection member to a skin site of said patient, whereby said plurality of stratum corneum-piercing microprotrusions pierce the stratum corneum and deliver said PTH-based agent to said patient; and
removing said microprojection member from said skin site. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81)
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82. A method of improving the pharmacokinetics of a transdermally delivered PTH-based agent, comprising the steps of:
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providing a microprojection member having a plurality of stratum corneum-piercing microprotrusions, said microprotrusion member having a coating disposed thereon, said coating including at least one PTH-based agent;
applying said microprojection member to a skin site of said patient, whereby said plurality of stratum corneum-piercing microprotrusions pierce the stratum corneum and deliver said PTH-based agent to said patient; and
removing said microprojection member from said skin site;
wherein said delivery of the PTH-based agent has improved pharmacokinetics compared to pharmacokinetics characteristic of subcutaneous delivery. - View Dependent Claims (83, 84, 85, 86)
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Specification