Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling
First Claim
1. A method of detecting cardiopulmonary coupling between heart rate variability and respiration of a subject, comprising:
- accessing a first series of physiological data representing respiration dynamics of the subject;
accessing a second series of physiological data representing heart rate dynamics of the subject, said second series being temporally aligned with said first series; and
detecting cardiopulmonary coupling between said first series and said second series.
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Abstract
An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal (NN) interval series. The amplitude variations in the QRS complex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross power. Using the appropriate thresholds for the coherent cross power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined.
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Citations
20 Claims
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1. A method of detecting cardiopulmonary coupling between heart rate variability and respiration of a subject, comprising:
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accessing a first series of physiological data representing respiration dynamics of the subject;
accessing a second series of physiological data representing heart rate dynamics of the subject, said second series being temporally aligned with said first series; and
detecting cardiopulmonary coupling between said first series and said second series. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A computer program product comprising a computer useable medium having computer readable program code functions embedded in said medium for causing a computer to detect cardiopulmonary coupling between heart rate variability and respiration of a subject, comprising:
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a first computer readable program code function that causes the computer to access a first series of physiological data representing respiration dynamics of the subject;
a second computer readable program code function that causes the computer to access a second series of physiological data representing heart rate dynamics of the subject, said second series being temporally aligned with said first series; and
a third computer readable program code function that causes the computer to detect cardiopulmonary coupling between said first series and said second series. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification