Methods and devices for improving delivery of a substance to skin
First Claim
1. A method of deposition of a substance to a human subject'"'"'s skin comprising deposition of the substance at a pre-selected depth at a controlled rate and pressure wherein greater than 90% of the injected volume of the substance is deposited within the pre-selected depth.
2 Assignments
0 Petitions
Accused Products
Abstract
A method of delivery of a substance to a human subject'"'"'s skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of s pre-selected volume of the substance, e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.
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Citations
15 Claims
- 1. A method of deposition of a substance to a human subject'"'"'s skin comprising deposition of the substance at a pre-selected depth at a controlled rate and pressure wherein greater than 90% of the injected volume of the substance is deposited within the pre-selected depth.
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3. A method for improved bolus delivery of a substance to a human subject'"'"'s skin comprising:
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(a) delivering the substance over a period of no more than 10 minutes; and
(b) depositing the substance into a pre-selected compartment of the skin, wherein the delivery is performed at a controlled rate and at a pressure between 0.1 psi to 200 psi. - View Dependent Claims (4, 5, 6, 7)
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8. A method for improved bolus delivery of a substance to a human subject'"'"'s skin comprising:
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(a) delivering the substance over a period of no more than 10 minutes; and
(b) depositing the substance into a pre-selected compartment of the skin, wherein the delivery is performed at a controlled pressure and at a rate up to 3500 μ
L/min. - View Dependent Claims (9, 10, 11, 12, 13)
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Specification