Methods and apparatus for extrusion of vesicles at high pressure
First Claim
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1. A method of producing a suspension of vesicles comprising extruding a mixture comprising a lipid through a hydrophilic screen membrane at high pressure.
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Abstract
This invention relates in general to methods and devices for producing vesicles, including micelles, and particularly liposomes, by extruding solutions comprising materials capable of forming vesicles through a screen membrane at high pressure.
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Citations
74 Claims
- 1. A method of producing a suspension of vesicles comprising extruding a mixture comprising a lipid through a hydrophilic screen membrane at high pressure.
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59. A device for extruding an aqueous suspension of lipids at high pressure comprising a hydrophilic screen membrane and means for entry and exit of liquid under high pressure.
- 64. A method of producing liposomes comprising extruding a mixture comprising a lipid through a hydrophilic membrane at pressures greater than about 8,000 psi.
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