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Liposome compositions for the delivery of macromolecules

  • US 20050260260A1
  • Filed: 05/19/2005
  • Published: 11/24/2005
  • Est. Priority Date: 05/19/2004
  • Status: Abandoned Application
First Claim
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1. A liposome composition for delivery of a therapeutic agent, comprising:

  • (a) From 1 to 10 mol percent of one or more lipids derivatized with a hydrophilic polymer (b) the remainder of the lipids not containing cholesterol, sterols or derivatives thereof and not bearing a positive net charge when between pH 5 and 9, wherein said lipids possess a measurable gel to fluid lipid membrane phase transition temperature that exists between 10 and 45 degrees Celsius when each unique lipid component is measured individually in the fully-hydrated state between pH 5 and 9. (c) a therapeutic or diagnostic agent, having a molecular weight greater than 3000 Daltons, that is completely encapsulated inside the liposome.

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