Compositions for sleeping disorders
First Claim
6. A composition comprising an effective amount of at least two compounds as defined in formulae I, II, or IV, wherein the composition is effective for treating a disorder selected from the group consisting of insomnia, depression-related disease, stress-related disease, depression-related sleep disorder, neurodegeneration diseases, Alzheimer'"'"'s disease, Pick'"'"'s disease, spinocerbellar degeneration, Parkinson'"'"'s disease, chorea, glaucoma, amyotrophic lateral sclerosis, senile macular degeneration, hepatic encephalopathy, demyelinating diseases, Lewy body dementia, multi-infarct dementia, multiple sclerosis and combinations thereof, wherein the compound of formulae I or II has a structure of in which:
- R1, R2, and R12 taken independently can be absence, hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
R3, R4, R5, R6, R7, R8, R9, R10, R11, R13 and R20 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
Z1, Z2 and Z3 taken independently can be oxygen (O), sulphur (S), or NH;
Z1 and R1 taken together can be a moiety of formula III;
where R14, R15, R16, R17, R18 and R19 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule; and
Z4 can be oxygen (O), sulphur (S), or NH, wherein the compound of Formula IV has a structure of in which;
R1, R6, and R8 taken independently can be absence, hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
R2, R3, R4, R5, R7, R9, R10, R11, R12 and R13 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
Z1, Z2 and Z3 taken independently can be oxygen (O), sulphur (S), or NH; and
Z1 and R1 taken together can be a moiety of formula III;
in which R13, R14, R15, R16, R17, and R18 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule.
1 Assignment
0 Petitions
Accused Products
Abstract
Provided herein is a composition that contains an effective amount of one or more compounds for treating, preventing, or ameliorating a disorder such as insomnia or another sleeping disorder and using the composition.
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Citations
23 Claims
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6. A composition comprising an effective amount of at least two compounds as defined in formulae I, II, or IV,
wherein the composition is effective for treating a disorder selected from the group consisting of insomnia, depression-related disease, stress-related disease, depression-related sleep disorder, neurodegeneration diseases, Alzheimer'"'"'s disease, Pick'"'"'s disease, spinocerbellar degeneration, Parkinson'"'"'s disease, chorea, glaucoma, amyotrophic lateral sclerosis, senile macular degeneration, hepatic encephalopathy, demyelinating diseases, Lewy body dementia, multi-infarct dementia, multiple sclerosis and combinations thereof, wherein the compound of formulae I or II has a structure of in which: -
R1, R2, and R12 taken independently can be absence, hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
R3, R4, R5, R6, R7, R8, R9, R10, R11, R13 and R20 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
Z1, Z2 and Z3 taken independently can be oxygen (O), sulphur (S), or NH;
Z1 and R1 taken together can be a moiety of formula III;
where R14, R15, R16, R17, R18 and R19 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule; and
Z4 can be oxygen (O), sulphur (S), or NH, wherein the compound of Formula IV has a structure of in which;
R1, R6, and R8 taken independently can be absence, hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
R2, R3, R4, R5, R7, R9, R10, R11, R12 and R13 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule;
Z1, Z2 and Z3 taken independently can be oxygen (O), sulphur (S), or NH; and
Z1 and R1 taken together can be a moiety of formula III;
in which R13, R14, R15, R16, R17, and R18 taken independently can be hydrogen, halo, alkyl, substituted alkyl, alkoxy, cycloalkyl, heterocyclic, alkenyl alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, alkoxy, substituted alkoxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, thiol, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, fulfonyl, substituted sulfonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, peptide, polyether, polyester, polypeptide, protein, polyphosphazene, polyalkylene oxide, polyalkylene glycol, polyethylene glycol, polyalkylene, a bioactive agent, or a drug molecule. - View Dependent Claims (1, 2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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21-1. The composition of claim 6, which is a nutraceutical composition or dietary supplement composition.
Specification