Methods for treating inflammatory and autoimmune diseases

• US 20050261246A1
• Filed: 03/04/2005
• Published: 11/24/2005
• Est. Priority Date: 03/05/2004
• Status: Abandoned Application

• Current Assignee: Arizona Board of Regents (University of Arizona)
• Original Assignee: Arizona Board of Regents (University of Arizona)
• Inventors: Wilson, David, Ananieva, Olga, Chang, Yung, Pettit, George R., Lubahn, Cheri, Lorton, Dianne
• Application Number:
  US11/071,994
• Publication Number:
  US 20050261246A1
• Time in Patent Office: Days
• US Class Current: 514/80
• CPC Class Codes: A61K 31/4741 condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
• CPC Class Codes: A61K 31/675 having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention provides methods for treating inflammatory conditions, rheumatoid diseases, autoimmune conditions, and conditions associated with bone loss, comprising administering to a subject with an inflammatory condition an amount effective to treat the condition of a compound selected from the group consisting of narcistatin, pancratistatin, pancratastatin-7′ phosphate and pancratastatin-3′,4′ cyclic phosphate, or pharmaceutically acceptable salts thereof.

Claims

1. A method for treating an inflammatory condition comprising administering to a subject with an inflammatory condition an amount effective to treat the inflammatory condition of a compound selected from the group consisting of narcistatin, pancratistatin, pancratastatin-7′

phosphate and pancratastatin-3′

,4′

cyclic phosphate, or pharmaceutically acceptable salts thereof.

2. The method of claim 1 wherein the inflammatory condition is selected from the group consisting of arthritis, inflammatory bowel disease, asthma, emphysema, ulcerative colitis, rheumatoid arthritis, juvenile chronic arthritis, Crohn'"'"'s disease, Sjö

rgen'"'"'s disease, systemic lupus erythematosus, psoriasis, sciatica, atherosclerosis, infection, strain, sprain, cartilage damage, trauma, and recent orthopedic surgery.

3. A method for treating arthritis, comprising administering to a subject with arthritis an amount effective to treat arthritis of a compound selected from the group consisting of narcistatin, pancratistatin, pancratastatin-7′

phosphate and pancratastatin-3′

,4′

cyclic phosphate, or pharmaceutically acceptable salts thereof.

4. The method of claim 3 wherein the arthritis comprises rheumatoid arthritis

5. The method of claim 3 wherein the arthritis comprises osteoarthritis.

6. A method for one or more of reducing bone loss in a subject, treating a rheumatoid disease, and/or treating an autoimmune disorder, comprising administering to a subject at risk of bone loss, suffering from a rheumatoid disease, and/or suffering from an autoimmune disorder an amount effective to reduce bone loss, treat a rheumatoid disease, and/or treat an autoimmune disorder of a compound selected from the group consisting of narcistatin, pancratistatin, pancratastatin-7′

phosphate and pancratastatin-3′

,4′

cyclic phosphate, or pharmaceutically acceptable salts thereof.

7. The method of claim 6 wherein the subject suffers from one or more conditions selected from the group consisting of osteoporosis, osteoarthritis, Paget'"'"'s disease, humoral hypercalcemia of malignancy, hypercalcemia from tumors metastatic to bone, and periodontal disease.

8. A method for treating one or more disorders selected from the group consisting of osteoporosis, osteoarthritis, Paget'"'"'s disease, humoral hypercalcemia of malignancy, hypercalcemia from tumors metastatic to bone, and periodontal disease, comprising administering to a subject with one or more of the disorders an amount effective to treat the one or more disorders of a compound selected from the group consisting of sodium narcistatin, pancratistatin, pancratastatin-7′

phosphate and pancratastatin-3′

,4′

cyclic phosphate, or pharmaceutically acceptable salts thereof.

9. The method of claim 8 wherein the subject suffers from osteoporosis.

10. The method of claim 8 wherein the subject suffers from osteoarthritis.

11. The method of claim 8 wherein the subject suffers from Paget'"'"'s disease.

12. The method of claim 8 wherein the subject suffers from humoral hypercalcemia of malignancy.

13. The method of claim 8 wherein the subject suffers from hypercalcemia from tumors metastatic to bone.

14. The method of claim 8 wherein the subject suffers from periodontal disease.

15. A method for reducing cellular production of one or more of vascular endothelial growth factor, nitric oxide, IL-1, MCP, and/or TNFα

in a subject in need thereof comprising administering to the subject an amount effective to reduce cellular production or one or more of vascular endothelial growth factor, nitric oxide, IL-1, MCP, and/or TNFα

of a compound selected from the group consisting of narcistatin, pancratistatin, pancratastatin-7′

phosphate and pancratastatin-3′

,4′

cyclic phosphate, or pharmaceutically acceptable salts thereof.