Biologic replacement for fibrin clot
First Claim
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1. A composition comprising soluble type I collagen, an extracellular matrix protein, and a platelet.
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Abstract
The invention provides composition and methods for repairing a ruptured anterior cruciate ligament.
45 Citations
24 Claims
- 1. A composition comprising soluble type I collagen, an extracellular matrix protein, and a platelet.
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5-6. -6. (canceled)
- 7. A composition comprising soluble type I collagen, a platelet and a neutralizing agent.
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9. (canceled)
- 11. A tissue-adhesive composition formulated for administration to a patient, comprising collagen, a neutralizing agent and a platelet.
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16. (canceled)
- 17. A tissue-adhesive composition formulated for administration to a patient, comprising soluble type I collagen, an extracellular matrix protein, and a platelet derived from said patient.
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19. A method of treating an intra-articular injury in a subject, the method comprising:
- contacting the ends of a ruptured tissue from the subject with a composition comprising soluble type I collagen, a platelet, and at least one of an extracellular protein and a neutralizing agent.
- View Dependent Claims (20, 21)
- 22. A method of treating an extra-articular injury in a subject, the method comprising contacting the ends of a ruptured tissue from the subject with a composition comprising soluble type I collagen, a platelet, and at least one of an extracellular protein and a neutralizing agent.
Specification