Xenotransplant for CNS therapy

• US 20050265977A1
• Filed: 01/14/2005
• Published: 12/01/2005
• Est. Priority Date: 04/30/1999
• Status: Abandoned Application

• Current Assignee: Neurotrophincell Pty, Limited
• Original Assignee: Neurotrophincell Pty, Limited
• Inventors: Elliott, Robert Bartlett, Skinner, Stephen John Martin, Borlongan, Cesar Venturina, Williams, Christopher Edward, Vasconcellos, Alfred, Emerich, Dwaine
• Application Number:
  US11/036,202
• Publication Number:
  US 20050265977A1
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: A61K 2035/128 capsules, e.g. microcapsules
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: A61K 35/30 Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
• CPC Class Codes: A61K 9/0085 Brain, e.g. brain implants; Spinal cord
• CPC Class Codes: A61K 9/4816 Wall or shell material
• CPC Class Codes: A61L 27/3813 Epithelial cells, e.g. keratinocytes, urothelial cells
• CPC Class Codes: A61L 27/383 Nerve cells, e.g. dendritic cells, Schwann cells
• CPC Class Codes: A61L 27/3878 Nerve tissue, brain, spinal cord, nerves, dura mater
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C12N 5/0618 Cells of the nervous system
• CPC Class Codes: C12N 5/069 Vascular Endothelial cells

Abstract

Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal.

Claims

1. An implant comprising living cells collected from the choroid plexus of a mammal, at least some of which cells are choroid epithelial cells, said implant secreting at least one product that has a beneficial effect on a neurological disease when transplanted into a recipient mammal suffering from said neurological disease.

2. An implant as claimed in claim 1, wherein said living cells are encapsulated within a biocompatible capsule, the wall of which capsule is at least partially composed of a semi-permeable membrane that admits metabolites for sustaining the cells, blocks access by factors of the immune system of the recipient mammal, and allows an effective amount of one or more expressed products to exit from said implant.

3. An implant as claimed in claim 2, wherein said biocompatible capsule has an inner layer including an effective amount of a laminin;

said laminin serving as a physical substrate for said living cells thereby providing orientation and support for said cells.

4. An implant as claimed in claim 3, wherein said biocompatible capsule comprises a globular containment means that holds living cells.

5. An implant as claimed in claim 3, wherein said biocompatible capsule comprises a tubular containment means that holds living cells;

the implant secreting said at least one product when implanted within a ventricle of the brain of the recipient mammal, so that the product secreted from said implant accesses at least some regions of the central nervous system.

6. An implant as claimed in claim 1, wherein said living cells are taken from the choroid plexus of a fetal or neonatal mammal.

7. An implant as claimed in claim 6, wherein said living cells are obtained from the choroid plexus of a neonatal porcine.

8. An implant as claimed in claim 6, wherein at least some of said living cells have undergone subsequent modification in order to increase the production of at least one product that has a beneficial effect on a neurological disease.

9. A method of treating a neurological disorder in a mammal in need thereof, comprising implanting in or near the brain of said mammal an implant as claimed in claim 1.

10. A method as claimed in claim 9, wherein said neurological disorder is Alzheimer'"'"'s disease, Parkinson'"'"'s disease, epilepsy, Huntington'"'"'s disease, stroke, motor neurone disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis, aging, vascular disease, Menkes Kinky Hair Syndrome, Wilson'"'"'s disease, trauma, injury or damage to the nervous system.

11. A method as claimed in claim 10, wherein said neurological disorder is Huntington'"'"'s disease.

12. A method as claimed in claim 10, wherein said neurological disorder is a stroke.

13. A method as claimed in claim 10, wherein said neurological disorder is amyotrophic lateral sclerosis (ALS).

14. A method as claimed in claim 8, wherein said implant comprises living cells obtained from the choroid plexus of a neonatal porcine.